DC Field | Value | Language |
---|---|---|
dc.contributor.author | LEEJEONGHO | - |
dc.contributor.author | Jeong, Hyeon Seon | - |
dc.contributor.author | Lee, Dong Hyun | - |
dc.contributor.author | Beack, Songeun | - |
dc.contributor.author | Kim, Taeyeon | - |
dc.contributor.author | Lee, Geon-Hui | - |
dc.contributor.author | Park, Won Chan | - |
dc.contributor.author | Kim, Chulhong | - |
dc.contributor.author | Kim, Ki Su | - |
dc.contributor.author | Hahn, Sei Kwang | - |
dc.date.accessioned | 2018-06-15T05:37:14Z | - |
dc.date.available | 2018-06-15T05:37:14Z | - |
dc.date.created | 2018-01-24 | - |
dc.date.issued | 2017-12 | - |
dc.identifier.issn | 2373-9878 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/50663 | - |
dc.description.abstract | Obesity is associated with the risk of developing several severe diseases, such as metabolic disorder, diabetes, and heart diseases. Despite wide investigation and trials, a noninvasive obesity therapy is still an important medical unmet need, targeting the abnormal adipose tissue. Here, we developed hyaluronate hollow gold nanosphere adipocyte-targeting peptide (HA-HAuNS-ATP) conjugates for the photothermal ablation of adipose tissues. The HA-HAuNS-ATP conjugate could be noninvasively delivered into the skin and effectively target to adipocytes in the subcutaneous. With near-infrared laser illumination, HA-HAuNS-ATP conjugate enabled highly effective photothermal ablation of adipose tissues in C57BL/6 obesity mice. The photoacoustic imaging confirmed the successful transdermal delivery and the photothermal lipolysis of HA-HAuNS-ATP conjugate. Taken together, the transdermal HA-HAuNS-ATP conjugate might have a great potential for noninvasive photothermal lipolysis. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | ACS BIOMATERIALS SCIENCE & ENGINEERING | - |
dc.subject | TRANSDERMAL DRUG-DELIVERY | - |
dc.subject | ABLATION THERAPY | - |
dc.subject | ADIPOSE-TISSUE | - |
dc.subject | SKIN-CANCER | - |
dc.subject | OBESITY | - |
dc.subject | NANOPARTICLES | - |
dc.subject | COMPLEX | - |
dc.subject | RISK | - |
dc.title | Targeted Hyaluronate-Hollow Gold Nanosphere Conjugate for Anti-Obesity Photothermal Lipolysis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acsbiomaterials.7b00549 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | ACS BIOMATERIALS SCIENCE & ENGINEERING, v.3, no.12, pp.3646 - 3653 | - |
dc.identifier.wosid | 000418110600059 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 3653 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 3646 | - |
dc.citation.title | ACS BIOMATERIALS SCIENCE & ENGINEERING | - |
dc.citation.volume | 3 | - |
dc.contributor.affiliatedAuthor | LEEJEONGHO | - |
dc.contributor.affiliatedAuthor | Beack, Songeun | - |
dc.contributor.affiliatedAuthor | Kim, Taeyeon | - |
dc.contributor.affiliatedAuthor | Lee, Geon-Hui | - |
dc.contributor.affiliatedAuthor | Park, Won Chan | - |
dc.contributor.affiliatedAuthor | Kim, Chulhong | - |
dc.contributor.affiliatedAuthor | Hahn, Sei Kwang | - |
dc.identifier.scopusid | 2-s2.0-85038210521 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 1 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | TRANSDERMAL DRUG-DELIVERY | - |
dc.subject.keywordPlus | ABLATION THERAPY | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | SKIN-CANCER | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | hollow gold nanosphere | - |
dc.subject.keywordAuthor | hyaluronate | - |
dc.subject.keywordAuthor | adipocyte-targeting peptide | - |
dc.subject.keywordAuthor | obesity | - |
dc.subject.keywordAuthor | photothermal lipolysis | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Materials Science | - |
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