DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Seong Jeong | - |
dc.contributor.author | Kim, Ji-Hae | - |
dc.contributor.author | Song, Mi-Young | - |
dc.contributor.author | Sung, Young Chul | - |
dc.contributor.author | Lee, Seung-Woo | - |
dc.contributor.author | PARK, YUN JI | - |
dc.date.accessioned | 2018-06-15T05:48:02Z | - |
dc.date.available | 2018-06-15T05:48:02Z | - |
dc.date.created | 2017-12-21 | - |
dc.date.issued | 2017-11 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/50855 | - |
dc.description.abstract | Programmed cell death-1 (PD-1) is a coinhibitory molecule and plays a pivotal role in immune regulation. Here, we demonstrate a role for PD-1 in pathogenesis of inflammatory bowel disease (IBD). Wild-type (WT) mice had severe wasting disease during experimentally induced colitis, while mice deficient for PD-1 (PD-1(-/-)) did not develop colon inflammation. Interestingly, PD-1(-/-) mice cohoused with WT mice became susceptible to colitis, suggesting that resistance of PD-1(-/-) mice to colitis is dependent on their gut microbiota. 16S rRNA gene-pyrosequencing analysis showed that PD-1(-/-) mice had altered composition of gut microbiota with significant reduction in Rikenellaceae family. These altered colon bacteria of PD-1(-/-) mice induced less amount of inflammatory mediators from colon epithelial cells, including interleukin (IL)-6, and inflammatory chemokines. Taken together, our study indicates that PD-1 expression is involved in the resistance to experimental colitis through altered bacterial communities of colon. | - |
dc.language | English | - |
dc.publisher | 생화학분자생물학회 | - |
dc.relation.isPartOf | BMB Reports | - |
dc.title | PD-1 deficiency protects experimental colitis via alteration of gut microbiota | - |
dc.type | Article | - |
dc.identifier.doi | 10.5483/BMBRep.2017.50.11.165 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BMB Reports, v.50, no.11, pp.578 - 583 | - |
dc.identifier.kciid | ART002285718 | - |
dc.identifier.wosid | 000417178900009 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 583 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 578 | - |
dc.citation.title | BMB Reports | - |
dc.citation.volume | 50 | - |
dc.contributor.affiliatedAuthor | Sung, Young Chul | - |
dc.contributor.affiliatedAuthor | Lee, Seung-Woo | - |
dc.contributor.affiliatedAuthor | PARK, YUN JI | - |
dc.identifier.scopusid | 2-s2.0-85035810971 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 2 | - |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | IBD | - |
dc.subject.keywordAuthor | Colitis | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Metagenomics | - |
dc.subject.keywordAuthor | Microbiota | - |
dc.subject.keywordAuthor | PD-1 | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
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