DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang Moon Cheol | - |
dc.contributor.author | Park Han Wook | - |
dc.contributor.author | Choi Dong-Hoon | - |
dc.contributor.author | Choi Young Woo | - |
dc.contributor.author | Park Yunji | - |
dc.contributor.author | Sung Young Chul | - |
dc.contributor.author | Lee Seung-Woo | - |
dc.date.accessioned | 2018-06-15T05:48:27Z | - |
dc.date.available | 2018-06-15T05:48:27Z | - |
dc.date.created | 2017-12-21 | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/50863 | - |
dc.description.abstract | Developing a novel vaccine that can be applied against multiple strains of influenza virus is of utmost importance to human health. Previously, we demonstrated that the intranasal introduction of Fc-fused IL-7 (IL-7-mFc), a long-acting cytokine fusion protein, confers long-lasting prophylaxis against multiple strains of influenza A virus (IAV) by inducing the development of lung-resident memory-like T cells, called TRM-like cells. Here, we further investigated the mechanisms of IL-7-mFc-mediated protective immunity to IAVs. First, we found that IL-7-mFc treatment augments the accumulation of pulmonary T cells in 2 ways: recruiting blood circulating T cells into the lung and expanding T cells at the lung parenchyma. Second, the blockade of T cell migration from the lymph nodes (LNs) with FTY720 treatment was not required for mounting the protective immunity to IAV with IL-7-mFc, suggesting a more important role of IL-7 in T cells in the lungs. Third, IL-7-mFc treatment also recruited various innate immune cells into the lungs. Among these cells, plasmacytoid dendritic cells (pDCs) play an important role in IL-7-mFc-mediated protective immunity through reducing the immunopathology and increasing IAV-specific cytotoxic T lymphocyte (CTL) responses. In summary, our results show that intranasal treatment with IL-7-mFc modulates pulmonary immune responses to IAV, affecting both innate and adaptive immune cells. ? 2017. The Korean Association of Immunologists. | - |
dc.language | English | - |
dc.publisher | 대한면역학회 | - |
dc.relation.isPartOf | Immune Network | - |
dc.title | Plasmacytoid dendritic cells contribute to the protective immunity induced by intranasal treatment with fc-fused interleukin-7 against lethal influenza virus infection | - |
dc.title.alternative | Plasmacytoid Dendritic Cells Contribute to the Protective Immunity Induced by Intranasal Treatment with Fc-fused Interleukin-7 against Lethal Influenza Virus Infection | - |
dc.type | Article | - |
dc.identifier.doi | 10.4110/in.2017.17.5.343 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Immune Network, v.17, no.5, pp.343 - 351 | - |
dc.identifier.kciid | ART002278310 | - |
dc.identifier.wosid | 000418284200008 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 351 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 343 | - |
dc.citation.title | Immune Network | - |
dc.citation.volume | 17 | - |
dc.contributor.affiliatedAuthor | Sung Young Chul | - |
dc.contributor.affiliatedAuthor | Lee Seung-Woo | - |
dc.identifier.scopusid | 2-s2.0-85033232504 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 2 | - |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | VACCINE | - |
dc.subject.keywordPlus | BIOLOGY | - |
dc.subject.keywordPlus | CD4(+) | - |
dc.subject.keywordPlus | LUNG | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordAuthor | Interleukin-7 | - |
dc.subject.keywordAuthor | Fc fusion protein | - |
dc.subject.keywordAuthor | Orthomyxoviridae | - |
dc.subject.keywordAuthor | Dendritic cells | - |
dc.subject.keywordAuthor | T-Lymphocytes | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Immunology | - |
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