Inhibition of C1-Ten PTPase activity reduces insulin resistance through IRS-1 and AMPK pathways
SCIE
SCOPUS
- Title
- Inhibition of C1-Ten PTPase activity reduces insulin resistance through IRS-1 and AMPK pathways
- Authors
- Jeong, Heeyoon; Koh, Ara; Lee, Jiyoun; Park, Dohyun; Lee, Jung Ok; Lee, Mi Nam; Jo, Kyung-Jin; Huynh Nguyen Khanh Tran; Kim, Eui; Min, Byung-Sun; Kim, Hyeon Soo; Berggren, Per-Olof; Ryu, Sung Ho
- Date Issued
- 2017-12
- Publisher
- NATURE PUBLISHING GROUP
- Abstract
- Insulin resistance causes type 2 diabetes; therefore, increasing insulin sensitivity is a therapeutic approach against type 2 diabetes. Activating AMP-activated protein kinase (AMPK) is an effective approach for treating diabetes, and reduced insulin receptor substrate-1 (IRS-1) protein levels have been suggested as a molecular mechanism causing insulin resistance. Thus, dual targeting of AMPK and IRS-1 might provide an ideal way to treat diabetes. We found that 15,16-dihydrotanshinone I (DHTS), as a C1-Ten protein tyrosine phosphatase inhibitor, increased IRS-1 stability, improved glucose tolerance and reduced muscle atrophy. Identification of DHTS as a C1-Ten inhibitor revealed a new function of C1-Ten in AMPK inhibition, possibly through regulation of IRS-1. These findings suggest that C1-Ten inhibition by DHTS could provide a novel therapeutic strategy for insulin resistance-associated metabolic syndrome through dual targeting of IRS-1 and AMPK.
- Keywords
- ACTIVATED PROTEIN-KINASE; PHOSPHATIDYLINOSITOL 3-KINASE ACTIVITY; TYPE-2 DIABETIC-PATIENTS; SKELETAL-MUSCLE; TYROSINE-PHOSPHATASE; RECEPTOR SUBSTRATE-1; GLUCOSE-TRANSPORT; NIDDM SUBJECTS; GROWTH; CELLS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50912
- DOI
- 10.1038/s41598-017-18081-8
- ISSN
- 2045-2322
- Article Type
- Article
- Citation
- SCIENTIFIC REPORTS, vol. 7, 2017-12
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- There are no files associated with this item.
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