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Cited 11 time in webofscience Cited 13 time in scopus
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Inhibition of C1-Ten PTPase activity reduces insulin resistance through IRS-1 and AMPK pathways SCIE SCOPUS

Title
Inhibition of C1-Ten PTPase activity reduces insulin resistance through IRS-1 and AMPK pathways
Authors
Jeong, HeeyoonKoh, AraLee, JiyounPark, DohyunLee, Jung OkLee, Mi NamJo, Kyung-JinHuynh Nguyen Khanh TranKim, EuiMin, Byung-SunKim, Hyeon SooBerggren, Per-OlofRyu, Sung Ho
Date Issued
2017-12
Publisher
NATURE PUBLISHING GROUP
Abstract
Insulin resistance causes type 2 diabetes; therefore, increasing insulin sensitivity is a therapeutic approach against type 2 diabetes. Activating AMP-activated protein kinase (AMPK) is an effective approach for treating diabetes, and reduced insulin receptor substrate-1 (IRS-1) protein levels have been suggested as a molecular mechanism causing insulin resistance. Thus, dual targeting of AMPK and IRS-1 might provide an ideal way to treat diabetes. We found that 15,16-dihydrotanshinone I (DHTS), as a C1-Ten protein tyrosine phosphatase inhibitor, increased IRS-1 stability, improved glucose tolerance and reduced muscle atrophy. Identification of DHTS as a C1-Ten inhibitor revealed a new function of C1-Ten in AMPK inhibition, possibly through regulation of IRS-1. These findings suggest that C1-Ten inhibition by DHTS could provide a novel therapeutic strategy for insulin resistance-associated metabolic syndrome through dual targeting of IRS-1 and AMPK.
Keywords
ACTIVATED PROTEIN-KINASE; PHOSPHATIDYLINOSITOL 3-KINASE ACTIVITY; TYPE-2 DIABETIC-PATIENTS; SKELETAL-MUSCLE; TYROSINE-PHOSPHATASE; RECEPTOR SUBSTRATE-1; GLUCOSE-TRANSPORT; NIDDM SUBJECTS; GROWTH; CELLS
URI
https://oasis.postech.ac.kr/handle/2014.oak/50912
DOI
10.1038/s41598-017-18081-8
ISSN
2045-2322
Article Type
Article
Citation
SCIENTIFIC REPORTS, vol. 7, 2017-12
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류성호RYU, SUNG HO
Dept of Life Sciences
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