Natural healing-inspired collagen-targeting surgical protein glue for accelerated scarless skin regeneration
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SCOPUS
- Title
- Natural healing-inspired collagen-targeting surgical protein glue for accelerated scarless skin regeneration
- Authors
- JEON, EUN YOUNG; CHOI, BONG HYUK; JUNG, DOOYUP; HWANG, BYEONGHEE; Cha, Hyung Joon
- Date Issued
- 2017-07
- Publisher
- Elsevier Ltd
- Abstract
- Skin scarring after deep dermal injuries is a major clinical problem due to the current therapies limited to established scars with poor understanding of healing mechanisms. From investigation of aberrations within the extracellular matrix involved in pathophysiologic scarring, it was revealed that one of the main factors responsible for impaired healing is abnormal collagen reorganization. Here, inspired by the fundamental roles of decorin, a collagen-targeting proteoglycan, in collagen remodeling, we created a scar-preventive collagen-targeting glue consisting of a newly designed collagen-binding mussel adhesive protein and a specific glycosaminoglycan. The collagen-targeting glue specifically bound to type I collagen in a dose-dependent manner and regulated the rate and the degree of fibrillogenesis. In a rat skin excisional model, the collagen-targeting glue successfully accelerated initial wound regeneration as defined by effective reepithelialization, neovascularization, and rapid collagen synthesis. Moreover, the improved dermal collagen architecture was demonstrated by uniform size of collagen fibrils, their regular packing, and a restoration of healthy tissue component. Collectively, our natural healing-inspired collagen-targeting glue may be a promising therapeutic option for improving the healing rate with high-quality and effective scar inhibition. ? 2017 Elsevier Ltd
- Keywords
- Glues; Gluing; Molluscs; Proteins; Surgery; Tissue; Collagen organizations; Dose-dependent manner; Extracellular matrices; Mussel adhesive proteins; Neo-vascularization; Re-epithelialization; Scarless healing; Surgical glues; Collagen; alpha smooth muscle actin; decorin; glycosaminoglycan; interstitial collagenase; messenger RNA; mussel adhesive protein; Smad7 protein; surgical glue; tissue inhibitor of metalloproteinase 1; transforming growth factor beta receptor 3; transforming growth factor beta1; wound healing promoting agent; animal cell; animal experiment; animal model; animal tissue; Article; cell differentiation; cell migration; cell proliferation; collagen fibril; collagen synthesis; concentration response; controlled study; device material; down regulation; epithelization; excision; extracellular matrix; female; gene expression; keratinocyte; neovascularization (pathology); nonhuman; polyacrylamide gel electrophoresis; priority journal; protein targeting; rat; reverse transcription polymerase chain reaction; scar formation; skin injury; upregulation; wound closure; wound healing
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50929
- DOI
- 10.1016/j.biomaterials.2017.04.041
- ISSN
- 0142-9612
- Article Type
- Article
- Citation
- Biomaterials, vol. 134, page. 154 - 165, 2017-07
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