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Cited 14 time in webofscience Cited 12 time in scopus
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Visualization of laser tattoo removal treatment effects in a mouse model by two-photon microscopy SCIE SCOPUS

Title
Visualization of laser tattoo removal treatment effects in a mouse model by two-photon microscopy
Authors
JANG, WON HYUKYoon, YeoreumKim, WonjoongKwon, SoonjaeLee, SeunghunSong, DukeChoi, Jong WoonKim, Ki Hean
Date Issued
2017-08
Publisher
OPTICAL SOC AMER
Abstract
Laser tattoo removal is an effective method of eliminating tattoo particles in the skin. However, laser treatment cannot always remove the unwanted tattoo completely, and there are risks of either temporary or permanent side effects. Studies using preclinical animal models could provide detailed information on the effects of laser treatment in the skin, and might help to minimize side effects in clinical practices. In this study, two-photon microscopy (TPM) was used to visualize the laser treatment effects on tattoo particles in both phantom specimens and in vivo mouse models. Fluorescent tattoo ink was used for particle visualization by TPM, and nanosecond (ns) and picosecond (ps) lasers at 532 nm were used for treatment. In phantom specimens, TPM characterized the fragmentation of individual tattoo particles by tracking them before and after the laser treatment. These changes were confirmed by field emission scanning electron microscopy (FE-SEM). TPM was used to measure the treatment efficiency of the two lasers at different laser fluences. In the mouse model, TPM visualized clusters of tattoo particles in the skin and detected their fragmentation after the laser treatment. Longitudinal TPM imaging observed the migration of cells containing tattoo particles after the laser treatment. These results show that TPM may be useful for the assessment of laser tattoo removal treatment in preclinical studies. (C) 2017 Optical Society of America
Keywords
OPTICAL COHERENCE TOMOGRAPHY; 3RD HARMONIC-GENERATION; IN-VIVO; MULTIPHOTON MICROSCOPY; INTRADERMAL TATTOOS; HUMAN SKIN; FLUORESCENCE; MOXIFLOXACIN; EVENTS; INJURY
URI
https://oasis.postech.ac.kr/handle/2014.oak/92063
DOI
10.1364/BOE.8.003735
ISSN
2156-7085
Article Type
Article
Citation
Biomedical Optics Express, vol. 8, no. 8, page. 3735 - 3748, 2017-08
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김기현KIM, KI HEAN
Dept of Mechanical Enginrg
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