Iodide-Selective Synthetic Ion Channels Based on Shape-Persistent Organic Cages
SCIE
SCOPUS
- Title
- Iodide-Selective Synthetic Ion Channels Based on Shape-Persistent Organic Cages
- Authors
- Benke, B.P.; Aich, P.; Kim, Y.; Kim, K.L.; Rohman, M.R.; Hong, S.; Hwang, I.-C.; Lee, E.H.; Roh, J.H.; Kim, K.
- Date Issued
- 2017-06
- Publisher
- AMER CHEMICAL SOC
- Abstract
- We report here a synthetic ion channel developed from a shape-persistent porphyrin-based covalent organic cage. The cage was synthesized by employing a synthetically economical dynamic covalent chemistry (DCC) approach. The organic cage selectively transports biologically relevant iodide ions over other inorganic anions by a dehydration-driven, channel mechanism as evidenced by vesicle-based fluorescence assays and planar lipid bilayer-based single channel recordings. Furthermore, the organic cage appears to facilitate iodide transport across the membrane of a living cell, suggesting that the cage could be useful as a biological tool that may replace defective iodide channels in living systems. ? 2017 American Chemical Society.
- Keywords
- Lipid bilayers; Dynamic covalent chemistry; Fluorescence assay; Inorganic anions; Iodide ion; Living cell; Living systems; Single channel recording; Synthetic ion channels; Ions; iodide; ion channel; porphyrin; anion transport; Article; controlled study; covalent bond; crystal structure; embryo; human; human cell; lipid bilayer; synthesis; voltage clamp technique
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/92096
- DOI
- 10.1021/jacs.7b02708
- ISSN
- 0002-7863
- Article Type
- Article
- Citation
- JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 139, no. 22, page. 7432 - 7435, 2017-06
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