Sclerodermatous chronic graft‐versus‐host disease induced by host T‐cell‐mediated autoimmunity
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SCOPUS
- Title
- Sclerodermatous chronic graft‐versus‐host disease induced by host T‐cell‐mediated autoimmunity
- Authors
- LEE, You Jeong
- Date Issued
- 2012-03
- Publisher
- NATURE PUBLISHING GROUP
- Abstract
- Despite a long-standing hypothesis that chronic graft-versus-host disease (cGVHD) is an autoimmune disorder, most mouse models of cGVHD have been developed on the assumption that donor T cells are essential for its development. Here we show that cGVHD may be caused by autoreactive host T cells in mice that have been lethally irradiated and grafted with T-cell-depleted allogeneic bone marrow cells. In this chimera, host T cells derived from radioresistant intrathymic T-cell precursors caused dermal fibrosis and periportal inflammation, without the requirement for donor T cells. The lack of host DCs within the thymus after high-dose irradiation allowed autoreactive host T cells to escape thymic negative selection. Moreover, the homeostatic expansion of these T cells may augment their autoreactivity. These findings indicate that host T-cell-mediated cGVHD is an autoimmune process that occurs following the grafting of T-cell-depleted BM cells into hosts with functioning thymuses. We propose, based on the present data, that host T-cell-dependent autoimmunity is a potential mechanism by which cGVHD is induced. Immunology and Cell Biology (2012) 90, 358-367; doi:10.1038/icb.2011.46; published online 31 May 2011
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/92449
- DOI
- 10.1038/icb.2011.46
- ISSN
- 0818-9641
- Article Type
- Article
- Citation
- IMMUNOLOGY AND CELL BIOLOGY, vol. 90, no. 3, page. 358 - 367, 2012-03
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