DC Field | Value | Language |
---|---|---|
dc.contributor.author | LEE, You Jeong | - |
dc.date.accessioned | 2018-10-04T05:57:29Z | - |
dc.date.available | 2018-10-04T05:57:29Z | - |
dc.date.created | 2018-09-30 | - |
dc.date.issued | 2012-03 | - |
dc.identifier.issn | 0818-9641 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/92449 | - |
dc.description.abstract | Despite a long-standing hypothesis that chronic graft-versus-host disease (cGVHD) is an autoimmune disorder, most mouse models of cGVHD have been developed on the assumption that donor T cells are essential for its development. Here we show that cGVHD may be caused by autoreactive host T cells in mice that have been lethally irradiated and grafted with T-cell-depleted allogeneic bone marrow cells. In this chimera, host T cells derived from radioresistant intrathymic T-cell precursors caused dermal fibrosis and periportal inflammation, without the requirement for donor T cells. The lack of host DCs within the thymus after high-dose irradiation allowed autoreactive host T cells to escape thymic negative selection. Moreover, the homeostatic expansion of these T cells may augment their autoreactivity. These findings indicate that host T-cell-mediated cGVHD is an autoimmune process that occurs following the grafting of T-cell-depleted BM cells into hosts with functioning thymuses. We propose, based on the present data, that host T-cell-dependent autoimmunity is a potential mechanism by which cGVHD is induced. Immunology and Cell Biology (2012) 90, 358-367; doi:10.1038/icb.2011.46; published online 31 May 2011 | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | IMMUNOLOGY AND CELL BIOLOGY | - |
dc.title | Sclerodermatous chronic graft‐versus‐host disease induced by host T‐cell‐mediated autoimmunity | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/icb.2011.46 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | IMMUNOLOGY AND CELL BIOLOGY, v.90, no.3, pp.358 - 367 | - |
dc.identifier.wosid | 000301848900017 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 367 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 358 | - |
dc.citation.title | IMMUNOLOGY AND CELL BIOLOGY | - |
dc.citation.volume | 90 | - |
dc.contributor.affiliatedAuthor | LEE, You Jeong | - |
dc.identifier.scopusid | 2-s2.0-84858704004 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 2 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | BONE-MARROW-TRANSPLANTATION | - |
dc.subject.keywordPlus | THYMOCYTE-THYMOCYTE INTERACTION | - |
dc.subject.keywordPlus | THYMIC DENDRITIC CELLS | - |
dc.subject.keywordPlus | SUBLETHAL IRRADIATION | - |
dc.subject.keywordPlus | LANGERHANS CELLS | - |
dc.subject.keywordPlus | HOMEOSTATIC PROLIFERATION | - |
dc.subject.keywordPlus | FUNCTIONAL-PROPERTIES | - |
dc.subject.keywordPlus | POSITIVE SELECTION | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordAuthor | autoimmunity | - |
dc.subject.keywordAuthor | chronic graft-versus-host disease | - |
dc.subject.keywordAuthor | host T cells | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Immunology | - |
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