MHC Class II-Restricted Interaction between Thymocytes Plays an Essential Role in the Production of Innate CD8(+) T Cells
SCIE
SCOPUS
- Title
- MHC Class II-Restricted Interaction between Thymocytes Plays an Essential Role in the Production of Innate CD8(+) T Cells
- Authors
- LEE, You Jeong
- Date Issued
- 2011-05-15
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Abstract
- We have recently shown that MHC class II-dependent thymocyte-thymocyte (T-T) interaction successfully generates CD4(+) T cells (T-T CD4(+) T cells), and that T-T CD4(+) T cells expressing promyelocytic leukemia zinc finger protein (PLZF) show an innate property both in mice and humans. In this article, we report that the thymic T-T interaction is essential for the conversion of CD8(+) T cells into innate phenotype in the physiological condition. CD8(+) T cells developed in the presence of PLZF(+) CD4(+) T cells showed marked upregulation of eomesodermin (Eomes), activation/memory phenotype, and rapid production of IFN-gamma on ex vivo stimulation. Their development was highly dependent on the PLZF expression in T-T CD4(+) T cells and the IL-4 secreted by PLZF(+) T-T CD4(+) T cells. The same events may take place in humans, as a substantial number of Eomes expressing innate CD8(+) T cells were found in human fetal thymi and spleens. It suggests that PLZF(+) T-T CD4(+) T cells in combination with Eomes(+) CD8(+) T cells might actively participate in the innate immune response against various pathogens, particularly in human perinatal period. The Journal of Immunology, 2011, 186: 5749-5757.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/92462
- DOI
- 10.4049/jimmunol.1002825
- ISSN
- 0022-1767
- Article Type
- Article
- Citation
- JOURNAL OF IMMUNOLOGY, vol. 186, no. 10, page. 5749 - 5757, 2011-05-15
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