Emerging themes in neuronal activity-dependent gene expression.
SCIE
SCOPUS
- Title
- Emerging themes in neuronal activity-dependent gene expression.
- Authors
- Madabhushi, RAM; KIM, TAE KYUNG
- Date Issued
- 2018-03
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Abstract
- In this review, we attempt to discuss emerging themes in the regulation of neuronal activity-regulated genes, focusing primarily on an important subset of immediate-early genes. We first discuss earlier studies that have illuminated the role of cis-acting elements within the promoters of immediate-early genes, the corresponding transcription factors that bind these elements, and the roles of major activity-regulated signaling pathways. However, our emphasis is on new studies that have revealed an important role for epigenetic and topological mechanisms, including enhancer-promoter interactions, enhancer RNAs (eRNAs), and activity-induced DNA breaks, that have emerged as important factors that govern the temporal dynamics of activity-induced gene transcription.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/94302
- DOI
- 10.1016/j.mcn.2017.11.009
- ISSN
- 1044-7431
- Article Type
- Article
- Citation
- MOLECULAR AND CELLULAR NEUROSCIENCE, vol. 87, page. 27 - 34, 2018-03
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- There are no files associated with this item.
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