DC Field | Value | Language |
---|---|---|
dc.contributor.author | KIM, TAE KYUNG | - |
dc.date.accessioned | 2018-12-04T01:54:23Z | - |
dc.date.available | 2018-12-04T01:54:23Z | - |
dc.date.created | 2018-11-20 | - |
dc.date.issued | 2017-09-27 | - |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/94306 | - |
dc.description.abstract | Individuals suffering from substance-use disorders develop strong associations between the drug's rewarding effects and environmental cues, creating powerful, enduring triggers for relapse. We found that dephosphorylated, nuclear histone deacetylase 5 (HDAC5) in the nucleus accumbens (NAc) reduced cocaine reward-context associations and relapse-like behaviors in a cocaine self-administration model. We also discovered that HDAC5 associates with an activity-sensitive enhancer of the Npas4 gene and negatively regulates NPAS4 expression. Exposure to cocaine and the test chamber induced rapid and transient NPAS4 expression in a small subpopulation of FOS-positive neurons in the NAc. Conditional deletion of Npas4 in the NAc significantly reduced cocaine conditioned place preference and delayed learning of the drug-reinforced action during cocaine self-administration, without affecting cue-induced reinstatement of drug seeking. These data suggest that HDAC5 and NPAS4 in the NAc are critically involved in reward-relevant learning and memory processes and that nuclear HDAC5 limits reinstatement of drug seeking independent of NPAS4. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.relation.isPartOf | NEURON | - |
dc.title | HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.neuron.2017.09.015 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NEURON, v.96, no.1, pp.130 - + | - |
dc.identifier.wosid | 000411845100015 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | + | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 130 | - |
dc.citation.title | NEURON | - |
dc.citation.volume | 96 | - |
dc.contributor.affiliatedAuthor | KIM, TAE KYUNG | - |
dc.identifier.scopusid | 2-s2.0-85031034998 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 9 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | PLACE PREFERENCE | - |
dc.subject.keywordPlus | DELTA-FOSB | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | REINSTATEMENT | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | WEBGESTALT | - |
dc.subject.keywordPlus | INCREASES | - |
dc.subject.keywordPlus | ENSEMBLES | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
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