DC Field | Value | Language |
---|---|---|
dc.contributor.author | KIM, TAE KYUNG | - |
dc.date.accessioned | 2018-12-04T01:54:27Z | - |
dc.date.available | 2018-12-04T01:54:27Z | - |
dc.date.created | 2018-11-20 | - |
dc.date.issued | 2017-02-07 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/94307 | - |
dc.description.abstract | Homeostatic scaling allows neurons to maintain stable activity patterns by globally altering their synaptic strength in response to changing activity levels. Suppression of activity by the blocking of action potentials increases synaptic strength through an upregulation of surface alpha-amino-3-hydroxy-5methyl-4-isoxazolepropionic acid (AMPA) receptors. Although this synaptic upscaling was shown to require transcription, the molecular nature of the intrinsic transcription program underlying this process and its functional significance have been unclear. Using RNA-seq, we identified 73 genes that were specifically upregulated in response to activity suppression. In particular, Neuronal pentraxin-1 (Nptx1) increased within 6 hr of activity blockade, and knockdown of this gene blocked the increase in synaptic strength. Nptx1 induction is mediated by calcium influx through the T-type voltage-gated calciumchannel, as well as two transcription factors, SRF and ELK1. Altogether, these results uncover a transcriptional program that specifically operates when neuronal activity is suppressed to globally coordinate the increase in synaptic strength. | - |
dc.language | English | - |
dc.publisher | Cell Press | - |
dc.relation.isPartOf | Cell Reports | - |
dc.title | An Intrinsic Transcriptional Program Underlying Synaptic Scaling during Activity Suppression | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.celrep.2017.01.033 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Cell Reports, v.18, no.6, pp.1512 - 1526 | - |
dc.identifier.wosid | 000397323400015 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 1526 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1512 | - |
dc.citation.title | Cell Reports | - |
dc.citation.volume | 18 | - |
dc.contributor.affiliatedAuthor | KIM, TAE KYUNG | - |
dc.identifier.scopusid | 2-s2.0-85011854022 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 2 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | RNA-POLYMERASE-II | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | NEURONAL-ACTIVITY | - |
dc.subject.keywordPlus | VISUAL-CORTEX | - |
dc.subject.keywordPlus | HOMEOSTATIC PLASTICITY | - |
dc.subject.keywordPlus | HIPPOCAMPAL-NEURONS | - |
dc.subject.keywordPlus | EXCITATORY SYNAPSE | - |
dc.subject.keywordPlus | DNA METHYLATION | - |
dc.subject.keywordPlus | NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | MULTIPLE FORMS | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.