DC Field | Value | Language |
---|---|---|
dc.contributor.author | KIM, TAE KYUNG | - |
dc.date.accessioned | 2018-12-04T01:54:37Z | - |
dc.date.available | 2018-12-04T01:54:37Z | - |
dc.date.created | 2018-11-20 | - |
dc.date.issued | 2016-01 | - |
dc.identifier.issn | 1097-6256 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/94310 | - |
dc.description.abstract | The c-fos gene (also known as Fos) is induced by a broad range of stimuli and is a reliable marker for neural activity. Its induction mechanism and available reporter mouse lines are based exclusively on c-fos promoter activity. Here we demonstrate that multiple enhancers surrounding the c-fos gene are crucial for ensuring robust c-fos response to various stimuli. Membrane depolarization, brain-derived neurotrophic factor (BDNF) and forskolin activate distinct subsets of the enhancers to induce c-fos transcription in neurons, suggesting that stimulus-specific combinatorial activation of multiple enhancers underlies the broad inducibility of the c-fos gene. Accordingly, the functional requirement of key transcription factors varies depending on the type of stimulation. Combinatorial enhancer activation also occurs in the brain. Providing a comprehensive picture of the c-fos induction mechanism beyond the minimal promoter, our study should help in understanding the physiological nature of c-fos induction in relation to neural activity and plasticity. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | NATURE NEUROSCIENCE | - |
dc.title | Stimulus-specific combinatorial functionality of neuronal c-fos enhancers | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/nn.4170 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NATURE NEUROSCIENCE, v.19, no.1, pp.75 - + | - |
dc.identifier.wosid | 000367254400015 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | + | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 75 | - |
dc.citation.title | NATURE NEUROSCIENCE | - |
dc.citation.volume | 19 | - |
dc.contributor.affiliatedAuthor | KIM, TAE KYUNG | - |
dc.identifier.scopusid | 2-s2.0-84953840289 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 40 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ACTIVITY-DEPENDENT REGULATION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL PROGRAM | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | MEMORY | - |
dc.subject.keywordPlus | ARCHITECTURE | - |
dc.subject.keywordPlus | PLASTICITY | - |
dc.subject.keywordPlus | LANDSCAPE | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
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