DC Field | Value | Language |
---|---|---|
dc.contributor.author | KIM, TAE KYUNG | - |
dc.date.accessioned | 2018-12-04T01:54:57Z | - |
dc.date.available | 2018-12-04T01:54:57Z | - |
dc.date.created | 2018-11-21 | - |
dc.date.issued | 2014-10-02 | - |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/94316 | - |
dc.description.abstract | Enhancer RNAs (eRNAs) are a class of long non-coding RNAs (IncRNA) expressed from active enhancers, whose function and action mechanism are yet to be firmly established. Here we show that eRNAs facilitate the transition of paused RNA polymerase II (RNAPII) into productive elongation by acting as a decoy for the negative elongation factor (NELF) complex upon induction of immediate early genes (IEGs) in neurons. eRNAs are synthesized prior to the culmination of target gene transcription and interact with the NELF complex. Knockdown of eRNAs expressed at neuronal enhancers impairs transient release of NELF from the specific target promoters during transcriptional activation, coinciding with a decrease in target mRNA induction. The enhancer-promoter interaction was unaffected by eRNA knockdown. Instead, chromatin looping might enable eRNAs to act locally at a specific promoter. Our findings highlight the spatiotemporally regulated action mechanism of eRNAs during early transcriptional elongation. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.relation.isPartOf | MOLECULAR CELL | - |
dc.title | Enhancer RNA facilitates NELF release from immediate early genes | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.molcel.2014.08.023 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | MOLECULAR CELL, v.56, no.1, pp.29 - 42 | - |
dc.identifier.wosid | 000344484400006 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 42 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 29 | - |
dc.citation.title | MOLECULAR CELL | - |
dc.citation.volume | 56 | - |
dc.contributor.affiliatedAuthor | KIM, TAE KYUNG | - |
dc.identifier.scopusid | 2-s2.0-84922391291 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 118 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | POLYMERASE-II ELONGATION | - |
dc.subject.keywordPlus | LONG NONCODING RNAS | - |
dc.subject.keywordPlus | TRANSCRIPTION ELONGATION | - |
dc.subject.keywordPlus | DROSOPHILA-MELANOGASTER | - |
dc.subject.keywordPlus | CHROMATIN ARCHITECTURE | - |
dc.subject.keywordPlus | INFLAMMATORY RESPONSE | - |
dc.subject.keywordPlus | DOMAIN KINASE | - |
dc.subject.keywordPlus | POL-II | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DSIF | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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