Amnion-Analogous Medical Device for Fetal Membrane Healing: A Preclinical Long-Term Study
SCIE
SCOPUS
- Title
- Amnion-Analogous Medical Device for Fetal Membrane Healing: A Preclinical Long-Term Study
- Authors
- LEE, JAE YEON; CHO, DONG WOO
- Date Issued
- 2018-09
- Publisher
- WILEY
- Abstract
- Although recent invasive fetal surgeries have improved fetal outcomes, fetal membrane rupture remains a major complication, leading to premature delivery, thus undermining the complete benefits of such procedures. A biocompatible amnion-analogous medical device (AMED) consisting of polycaprolactone framework and decellularized amniotic membrane (dAM)-derived hydrogel for restoration of amniotic membrane defect is developed using 3D printing technology. Its efficacy on healing iatrogenic fetal membrane defects in vitro is evaluated, showing that the dAM gel contains migratory and proliferative properties. The fetoscope feasibility of the developed AMED is assessed using a pregnant swine model. All animals had successfully recovered from anesthesia and the fetoscopic procedure and maintained a healthy condition until the end of the pregnancy. AMED exhibits superior surgical handling characteristics and is easy to manufacture, nonimmunogenic, biocompatible, and suitable for storage and transport for off-the-shelf use; hence, it can be used in successfully sealing defect sites, thus improving the preservation of the amniotic fluid, which in turn improves fetal survival and development.
- Keywords
- amnion; amnion analogous medical device; amnion fluid; anesthetic recovery; animal experiment; animal model; animal tissue; Article; biocompatibility; controlled study; cross linking; decellularization; extracellular matrix; feasibility study; fetoscopy; fetus development; fetus disease; fetus membrane; healing; human; human tissue; nonhuman; operation duration; pig; priority journal; shelf life; xenograft
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/94511
- DOI
- 10.1002/adhm.201800673
- ISSN
- 2192-2640
- Article Type
- Article
- Citation
- ADVANCED HEALTHCARE MATERIALS, vol. 7, no. 18, 2018-09
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