CD4+ T cells from MHC II-dependent thymocyte– thymocyte interaction provide efficient help for B cell
SCIE
SCOPUS
- Title
- CD4+ T cells from MHC II-dependent thymocyte– thymocyte interaction provide efficient help for B cell
- Authors
- Eun Ji Kim; Bomi Choi; Hana Moon; LEE, You Jeong; Yoon Kyeong Jeon; Seong Hoe Park; Tae Jin Kim; Kyeong Cheon Jung
- Date Issued
- 2011-11
- Publisher
- NATURE PUBLISHING GROUP
- Abstract
- Recently, a novel CD4(+) T-cell developmental pathway was reported that generates thymocyte-thymocyte (T-T) CD4(+) T cells. We established a mouse system (CIITA(tg)CIITApIV(-/-)) where thymic positive selection occurred only by major histocompatibility complex (MHC) class II+ thymocytes. T-T CD4(+) T cells selected via MHC class II-dependent T-T interaction are comprised of PLZF-negative and innate PLZF-positive populations. Until recently, the functional role of the PLZF-negative population was unclear. In this study, we demonstrate that naive T-T CD4(+) T cells provide B-cell help to a level comparable with that of naive conventional CD4(+) T cells. Considering the absence of PLZF expression in naive T-T CD4(+) T cells, these results suggest that PLZF-negative naive T-T CD4(+) T cells are functionally equivalent to conventional naive CD4(+) T cells in terms of B-cell help. Immunology and Cell Biology (2011) 89, 897-903; doi:10.1038/icb.2011.8; published online 1 March 2011
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/94543
- DOI
- 10.1038/icb.2011.8
- ISSN
- 0818-9641
- Article Type
- Article
- Citation
- IMMUNOLOGY AND CELL BIOLOGY, vol. 89, no. 8, page. 897 - 903, 2011-11
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