DC Field | Value | Language |
---|---|---|
dc.contributor.author | CHO, Minsoo | - |
dc.contributor.author | Han, Seulgi | - |
dc.contributor.author | Kim, Hyemin | - |
dc.contributor.author | Kim, Ki Su | - |
dc.contributor.author | HAHN, SEI KWANG | - |
dc.date.accessioned | 2019-03-07T01:14:36Z | - |
dc.date.available | 2019-03-07T01:14:36Z | - |
dc.date.created | 2018-06-07 | - |
dc.date.issued | 2018-03 | - |
dc.identifier.issn | 0920-5063 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/94990 | - |
dc.description.abstract | Human parathyroid hormone 1-34 fragment (PTH1-34) has been used as a FDA-approved therapeutics to treat osteoporosis by daily subcutaneous injection. In this work, we successfully developed PTH1-34 conjugated hyaluronic acid (HA) for the transdermal treatment of osteoporosis with improved patient compliance. HA-PTH1-34 conjugate was synthesized by the coupling reaction between aldehyde group introduced to HA and amine group of PTH1-34. After characterization by gel permeation chromatography (GPC) and ELISA, the biological effect of HA-PTH1-34 conjugate on the proliferation of human osteoblast cells was confirmed by in vitro calcium colorimetric assay and cAMP assay. Two-photon microscopy clearly visualized the effective skin penetration of FITC modified HA-PTH1-34 conjugate. The transdermally delivered HA-PTH1-34 conjugates elevated the blood calcium concentration for more than 2days, reflecting the feasibility for the treatment of osteoporosis. | - |
dc.language | English | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.relation.isPartOf | JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | - |
dc.title | Hyaluronate - parathyroid hormone peptide conjugate for transdermal treatment of osteoporosis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1080/09205063.2017.1399001 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, v.29, no.7-9, pp.793 - 804 | - |
dc.identifier.wosid | 000428299000007 | - |
dc.citation.endPage | 804 | - |
dc.citation.number | 7-9 | - |
dc.citation.startPage | 793 | - |
dc.citation.title | JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | - |
dc.citation.volume | 29 | - |
dc.contributor.affiliatedAuthor | Han, Seulgi | - |
dc.contributor.affiliatedAuthor | HAHN, SEI KWANG | - |
dc.identifier.scopusid | 2-s2.0-85034623968 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.subject.keywordPlus | SUSTAINED-RELEASE FORMULATION | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | MICRONEEDLES | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordAuthor | Human parathyroid hormone | - |
dc.subject.keywordAuthor | hyaluronic acid | - |
dc.subject.keywordAuthor | transdermal delivery | - |
dc.subject.keywordAuthor | osteoporosis | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Polymer Science | - |
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