In vivo photoacoustic monitoring of anti-obesity photothermal lipolysis
- Title
- In vivo photoacoustic monitoring of anti-obesity photothermal lipolysis
- Authors
- Lee, Donghyun; Lee, Jung Ho; Hahn, Sei Kwang; KIM, CHULHONG
- Date Issued
- 2018-01-29
- Publisher
- SPIE
- Abstract
- Obesity with a body mass index is greater than 30 kg/m(2) is one of the rapidly growing diseases in advanced societies and can lead to stroke, type 2 diabetes, and heart failure. Common methods of removing subcutaneous adipose tissues are liposuction and laser treatment. In this study, we used photoacoustic imaging to monitor the anti-obesity photothermal degradation process. To improve the photothermal lipid degradation efficiency without any invasive methods, we synthesized hyaluronic acid hollow hold nanosphere adipocyte targeting sequence peptide (HA-HAuNS-ATS) conjugates. The conjugate enhanced the skin penetration ability and biodegradability of the nanoparticles using hyaluronate and enhanced the targeting effect on adipose tissue with adipocyte targeting sequence peptide. Thus, the conjugate can be delivered to the adipose tissue by simply spreading the conjugate on the skin without any invasive method. Then, the photothermal lipolysis and delivery of the conjugate were photoacoustically monitored in vivo. These results demonstrate the potential for photoacoustic method to be applied for photothermal lipolysis monitoring.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/95189
- Article Type
- Conference
- Citation
- Conference on Photons Plus Ultrasound - Imaging and Sensing, 2018-01-29
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- There are no files associated with this item.
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