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Cited 82 time in webofscience Cited 81 time in scopus
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Characterization of cornea-specific bioink: high transparency, improved in vivo safety SCIE SCOPUS

Title
Characterization of cornea-specific bioink: high transparency, improved in vivo safety
Authors
Kim, HyeonjiPark, Moon-NyeoKim, JisooJang, JinahKim, Hong-KyunCho, Dong-Woo
Date Issued
2019-01
Publisher
SAGE PUBLICATIONS INC
Abstract
Corneal transplantation is a typical surgical procedure for severe corneal diseases. However, the waiting time for a donor cornea has gradually increased due to a decrease in supply caused by an aging population and increased cases of laser-based surgeries. Artificial corneas were developed to meet the increase in demand; however, these approaches have suffered from material deterioration resulted by the limited tissue integration. Here, we introduce a cornea-derived decellularized extracellular matrix (Co-dECM) as a bioink for corneal regeneration. The developed Co-dECM bioink had similar quantitative measurement results for collagen and GAGs compared with that of the native cornea and also had the proper transparency for vision. The differentiation potential of human turbinate-derived mesenchymal stem cells (hTMSCs) to a keratocyte lineage was only observed in the Co-dECM group. Moreover, the developed bioink did not have any cytotoxic effect on encapsulated cells for three-dimensional (3D) culture and has great biocompatibility evident by the xeno-implantation of the Co-dECM gel into mice and rabbits for two and one month, respectively. An in vivo safety similar to clinical-grade collagen was seen with the Co-dECM, which helped to maintain the keratocyte-specific characteristics in vivo, compared with collagen. Taken together, the Co-dECM bioink has the potential to be used in various types of corneal diseases based on its corneal-specific ability and design flexibility through 3D cell printing technology.
URI
https://oasis.postech.ac.kr/handle/2014.oak/95322
DOI
10.1177/2041731418823382
ISSN
2041-7314
Article Type
Article
Citation
JOURNAL OF TISSUE ENGINEERING, vol. 10, 2019-01
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조동우CHO, DONG WOO
Dept of Mechanical Enginrg
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