Stochastic Processes and Component Plasticity Governing DNA Mismatch Repair
SCIE
SCOPUS
- Title
- Stochastic Processes and Component Plasticity Governing DNA Mismatch Repair
- Authors
- Liu, Jiaquan; Lee, Jong-Bong; Fishel, Richard
- Date Issued
- 2018-10
- Publisher
- ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
- Abstract
- DNA mismatch repair (MMR) is a DNA excision-resynthesis process that principally enhances replication fidelity. Highly conserved MutS (MSH) and MutL (MLH/PMS) homologs initiate MMR and in higher eukaryotes act as DNA damage sensors that can trigger apoptosis. MSH proteins recognize mismatched nucleotides, whereas the MLH/PMS proteins mediate multiple interactions associated with downstream MMR events including strand discrimination and strand-specific excision that are initiated at a significant distance from the mismatch. Remarkably, the biophysical functions of the MLH/PMS proteins have been elusive for decades. Here we consider recent observations that have helped to define the mechanics of MLH/PMS proteins and their role in choreographing MMR. We highlight the stochastic nature of DNA interactions that have been visualized by single-molecule analysis and the plasticity of protein complexes that employ thermal diffusion to complete the progressions of MMR. (C) 2018 Elsevier Ltd. All rights reserved.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/95516
- DOI
- 10.1016/j.jmb.2018.05.039
- ISSN
- 0022-2836
- Article Type
- Article
- Citation
- JOURNAL OF MOLECULAR BIOLOGY, vol. 430, no. 22, page. 4456 - 4468, 2018-10
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.