Seeing Elastin: A Near-Infrared Zwitterionic Fluorescent Probe for In Vivo Elastin Imaging
SCIE
SCOPUS
- Title
- Seeing Elastin: A Near-Infrared Zwitterionic Fluorescent Probe for In Vivo Elastin Imaging
- Authors
- Su, Dongdong; Teoh, Chai Lean; Park, Sung-Jin; Kim, Jong-Jin; Samanta, Animesh; Bi, Renzhe; Dinish, U. S.; Oliyo, Malini; Piantino, Marie; Louis, Fiona; Matsusaki, Michiya; Kim, Seong Soon; Bae, Myung Ae; Chang, Young-Tae
- Date Issued
- 2018-05
- Publisher
- CELL PRESS
- Abstract
- Elastic fibers are present in a variety of tissues and are responsible for their resilience. Until now, no optical contrast agent in the near-infrared (NIR) wavelength range of 700-900 nm has been reported for the imaging of elastic fibers. Here, we report the discovery of a NIR zwitterionic elastin probe ElaNIR (elastin NIR) through fluorescent-image-based screening. The probe was successfully applied for in vitro, ex vivo, and in vivo imaging by various imaging modalities. Age-related elastin differences shown by in vivo fluorescent and photoacoustic imaging indicated that ElaNIR can be a potentially convenient tool for uncovering changes of elastin in live models.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/95893
- DOI
- 10.1016/j.chempr.2018.02.016
- ISSN
- 2451-9294
- Article Type
- Article
- Citation
- CHEM, vol. 4, no. 5, page. 1128 - 1138, 2018-05
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