Guest-responsive, Non-proteolytic Harvest of a Cell-sheet using Controllable Host-guest Chemistry
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- Title
- Guest-responsive, Non-proteolytic Harvest of a Cell-sheet using Controllable Host-guest Chemistry
- Authors
- Park, Kyeng Min; Shrinidhi, Annadka; Murray, James; Kim, Kimoon
- Date Issued
- 2018-04
- Publisher
- WILEY-V C H VERLAG GMBH
- Abstract
- A new non-proteolytic method to harvest a cell-sheet was demonstrated using controllable host-guest interactions which can be dissociated by treating a strong guest on demand. Fibroblast cells (NIH3T3) were grown to confluence on a 1,6-diammoniumhexane conjugated hyaluronic acid (DAH-HA) polymer which was anchored to a cucurbit[7]uril (CB[7]) surface using the host-guest interaction between DAH and CB[7]. Treating with a strong guest allowed the cultured cells to be detached from the surface as a free standing sheet. This approach demonstrated the great potential of controllable host-guest chemistry as a novel tool for non-proteolytic harvesting of cell-sheets useful for regenerative therapy.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/95920
- DOI
- 10.1002/ijch.201700084
- ISSN
- 0021-2148
- Article Type
- Article
- Citation
- ISRAEL JOURNAL OF CHEMISTRY, vol. 58, no. 3-4, page. 461 - 465, 2018-04
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