Detection of pathogenic bacteria using half-fragments antibody immobilized Fe3O4@FeSe2 core-shell nanoparticles
- Title
- Detection of pathogenic bacteria using half-fragments antibody immobilized Fe3O4@FeSe2 core-shell nanoparticles
- Authors
- EUN, JA KYUNG; JEON, SANGMIN
- Date Issued
- 2018-10-25
- Publisher
- 한국화학공학회
- Abstract
- Iron diselenide(FeSe2)-coated Fe3O4 magnetic nanoclusters (MNCs) were synthesized to detect pathogenic bacteria. MNCs were hydrothermally synthesized and coated with FeSe2 via co-reduction method. Hydrazine hydrate reduced Fe3O4 and Se powder to Fe2+ and Se22-, respectively. Co-reduction enabled FeSe2 shell to grow directly on the surface of MNCs. The stability and magnetization of Fe3O4@FeSe2 nanoparticles were controlled by addition of a small amount of FeCl3. FeSe2 shell enhanced the bacterial capture efficiency due to the favorable orientation of half fragments of anti-Escherichia coli antibodies through selenosulfide bond and the large surface area of the particles. As a results, the capture efficiency of Fe3O4@FeSe2 nanoparticles via selenosulfide-based immobilization of antibodies was two times higher than that of Fe3O4 nanoparticles through amide-based immobilization of antibodies.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/97486
- Article Type
- Conference
- Citation
- 한국화학공학회 2018년도 가을 총회 및 학술대회, 2018-10-25
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