Engineering Human Tissues via 3D Bioprinting Technology
- Title
- Engineering Human Tissues via 3D Bioprinting Technology
- Authors
- JANG, JIN AH; CHO, DONG WOO; UIJUNG, YONG; Hun-Jun Park; KIM, SEOK WON; Heejin Kim; Ju Young Park; Soo Jin Na; Hyeon Ji Kim; Moon Nyeo Park; Seung Hyun Choi; Sun Hwa Park; Sung Won Kim; Sang-Mo Kwon; Pum-Joon Kim
- Date Issued
- 2018-07-20
- Publisher
- 대한심장학회 기초과학연구회
- Abstract
- transplantation. In this study, stem cell-laden decellularized extracellular matrix bioinks are used in 3D printing of pre-vascularized and functional multi-material structures. The printed structure composed of spatial patterning of dual stem cells improves cell-to-cell interactions and differentiation capability and promotes functionality for tissue regeneration. The developed stem cell patch promoted strong vascularization and tissue matrix formation in vivo. The patterned patch exhibited enhanced cardiac functions, reduced cardiac hypertrophy and fibrosis, increased migration from patch to the infarct area, neo-muscle and capillary formation along with improvements in cardiac functions. Therefore, pre-vascularized stem cell patch provides cardiac niche-like microenvironment, resulting in beneficial effects on cardiac repair.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/97849
- Article Type
- Conference
- Citation
- 대한심장학회 기초과학연구회 하계심포지엄 2018, 2018-07-20
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- There are no files associated with this item.
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