Rapid identification of the pharmacophore in a peptoid inhibitor of the proteasome regulatory particle
SCIE
SCOPUS
- Title
- Rapid identification of the pharmacophore in a peptoid inhibitor of the proteasome regulatory particle
- Authors
- Lim, HS; Archer, CT; Kim, YC; Hutchens, T; Kodadek, T
- Date Issued
- 2008-03
- Publisher
- Royal Society of Chemistry
- Abstract
- Here we report a simple and effective method to identify the minimal pharmacophore in the first peptoid inhibitor of the 19S proteasome regulatory particle, which has led to the development of a derivative that exhibits improved cellular activity, presumably due to a reduction in mass of about two-fold and the elimination of positively charged lysine-like residues.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/9935
- DOI
- 10.1039/B717861A
- ISSN
- 1359-7345
- Article Type
- Article
- Citation
- CHEMICAL COMMUNICATIONS, no. 9, page. 1064 - 1066, 2008-03
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