DC Field | Value | Language |
---|---|---|
dc.contributor.author | JUNG, NAMYOUNG | - |
dc.contributor.author | KIM, TAE KYUNG | - |
dc.date.accessioned | 2021-09-03T03:57:41Z | - |
dc.date.available | 2021-09-03T03:57:41Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2021-05 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/106843 | - |
dc.description.abstract | In eukaryotes, the genome is hierarchically packed inside the nucleus, which facilitates physical contact between cis-regulatory elements (CREs), such as enhancers and promoters. Accumulating evidence highlights the critical role of higher-order chromatin structure in precise regulation of spatiotemporal gene expression under diverse biological contexts including lineage commitment and cell activation by external stimulus. Genomics and imaging-based technologies, such as Hi-C and DNA fluorescence in situ hybridization (FISH), have revealed the key principles of genome folding, while newly developed tools focus on improvement in resolution, throughput and modality at single-cell and population levels, and challenge the knowledge obtained through conventional approaches. In this review, we discuss recent advances in our understanding of principles of higher-order chromosome conformation and technologies to investigate 4D chromatin interactions. | - |
dc.language | English | - |
dc.publisher | 생화학분자생물학회 | - |
dc.relation.isPartOf | BMB Reports | - |
dc.title | Advances in higher-order chromatin architecture: the move towards 4D genome | - |
dc.type | Article | - |
dc.identifier.doi | 10.5483/BMBRep.2021.54.5.035 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BMB Reports, v.54, no.5, pp.233 - 245 | - |
dc.identifier.wosid | 000657384200001 | - |
dc.citation.endPage | 245 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 233 | - |
dc.citation.title | BMB Reports | - |
dc.citation.volume | 54 | - |
dc.contributor.affiliatedAuthor | JUNG, NAMYOUNG | - |
dc.contributor.affiliatedAuthor | KIM, TAE KYUNG | - |
dc.identifier.scopusid | 2-s2.0-85107237989 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | 3D genome | - |
dc.subject.keywordAuthor | 4D genome | - |
dc.subject.keywordAuthor | Chromatin architecture | - |
dc.subject.keywordAuthor | Chromatin loop | - |
dc.subject.keywordAuthor | Chromosome conformation | - |
dc.subject.keywordAuthor | Genome folding | - |
dc.subject.keywordAuthor | Hi-C | - |
dc.subject.keywordAuthor | Higher-order chromatin structure | - |
dc.subject.keywordAuthor | TAD | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.description.journalRegisteredClass | other | - |
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