Advances in higher-order chromatin architecture: the move towards 4D genome
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- Title
- Advances in higher-order chromatin architecture: the move towards 4D genome
- Authors
- JUNG, NAMYOUNG; KIM, TAE KYUNG
- Date Issued
- 2021-05
- Publisher
- 생화학분자생물학회
- Abstract
- In eukaryotes, the genome is hierarchically packed inside the nucleus, which facilitates physical contact between cis-regulatory elements (CREs), such as enhancers and promoters. Accumulating evidence highlights the critical role of higher-order chromatin structure in precise regulation of spatiotemporal gene expression under diverse biological contexts including lineage commitment and cell activation by external stimulus. Genomics and imaging-based technologies, such as Hi-C and DNA fluorescence in situ hybridization (FISH), have revealed the key principles of genome folding, while newly developed tools focus on improvement in resolution, throughput and modality at single-cell and population levels, and challenge the knowledge obtained through conventional approaches. In this review, we discuss recent advances in our understanding of principles of higher-order chromosome conformation and technologies to investigate 4D chromatin interactions.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/106843
- DOI
- 10.5483/BMBRep.2021.54.5.035
- ISSN
- 1976-6696
- Article Type
- Article
- Citation
- BMB Reports, vol. 54, no. 5, page. 233 - 245, 2021-05
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