Junctional membrane inositol 1,4,5-trisphosphate receptor complex coordinates sensitization of the silent EGF-induced Ca2+ signaling
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- Title
- Junctional membrane inositol 1,4,5-trisphosphate receptor complex coordinates sensitization of the silent EGF-induced Ca2+ signaling
- Authors
- Hur, EM; Park, YS; Huh, YH; Yoo, SH; Woo, KC; Choi, BH; Kim, KT
- Date Issued
- 2005-05-23
- Publisher
- ROCKEFELLER UNIV PRESS
- Abstract
- Ca2+ is a highly versatile intracellular signal that regulates many different cellular processes, and cells have developed mechanisms to have exquisite control over Ca2+ signaling. Epidermal growth factor ( EGF), which fails to mobilize intracellular Ca2+ when administrated alone, becomes capable of evoking [Ca2+](i) increase and exocytosis after bradykinin (BK) stimulation in chromaffin cells. Here, we provide evidence that this sensitization process is coordinated by a macromolecular signaling complex comprised of inositol 1,4,5- trisphosphate receptor type I(IP(3)R1), cAMP- dependent protein kinase (PKA), EGF receptor (EGFR), and an A-kinase anchoring protein, yotiao. The IP3R complex functions as a focal point to promote Ca2+ release in two ways: (1) it facilitates PKA-dependent phosphorylation of IP(3)R1 in response to BK-induced elevation of cAMP, and (2) it couples the plasmalemmal EGFR with IP(3)R1 at the Ca2+ store located juxtaposed to the plasma membrane. Our study illustrates how the junctional membrane IP3R complex connects different signaling pathways to define the fidelity and specificity of Ca2+ signaling.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/10690
- DOI
- 10.1083/JCB.200411034
- ISSN
- 0021-9525
- Article Type
- Article
- Citation
- JOURNAL OF CELL BIOLOGY, vol. 169, no. 4, page. 657 - 667, 2005-05-23
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