Characterization of the Gel-Spun Tubular Scaffold for Cardiovascular Tissue Engineering
SCIE
SCOPUS
- Title
- Characterization of the Gel-Spun Tubular Scaffold for Cardiovascular Tissue Engineering
- Authors
- Chung, Eun Na; Kim, Sang Heon; Ko, Young Gun; Kwon, Jae Hyun; HAN, JEONG WOO; Park, In Su; Han, Sung Sik; Kim, Soo Hyun
- Date Issued
- 2007-07
- Publisher
- Trans Tech Publications, Ltd.
- Abstract
- A tubular and fibrous scaffold was fabricated from an elastic polymer, poly (L-lactideco-epsilon-caprolactone) (PLCL; Mn 193,813, Mw 538,623) 50:50 by using a novel gel spinning apparatus. To characterize the gel-spun scaffold, we investigated morphology, tensile property, tissue in-growth rate and degradation rate. From SEM images, fibrous structure in the scaffold wasn't fabricated well in the condition of 4% gel concentration. In general, the thickness level of microfibers increased as the gel concentration increased. In addition, the gel-spun scaffolds showed stronger tensile properties in the circumferential direction than the longitudinal direction. 5%, 7.5%, 10% and 12.5% scaffolds were analyzed in both directions: circumferential direction and longitudinal direction. On the other hand, the gel-spun scaffolds have been implanted in mouse to examine the degradation rate in vivo and tissue in-growth aspects, compared to extruded scaffolds. Both shows very similar degradation rates, but the aspect in tissue in-growth was different. In conclusion, gel-spun PLCL scaffolds have good characteristics as a plausible scaffold for cardiovascular tissue engineering.
A tubular and fibrous scaffold was fabricated from an elastic polymer, poly (L-lactideco-epsilon-caprolactone) (PLCL; Mn 193,813, Mw 538,623) 50:50 by using a novel gel spinning apparatus. To characterize the gel-spun scaffold, we investigated morphology, tensile property, tissue in-growth rate and degradation rate. From SEM images, fibrous structure in the scaffold wasn't fabricated well in the condition of 4% gel concentration. In general, the thickness level of microfibers increased as the gel concentration increased. In addition, the gel-spun scaffolds showed stronger tensile properties in the circumferential direction than the longitudinal direction. 5%, 7.5%, 10% and 12.5% scaffolds were analyzed in both directions: circumferential direction and longitudinal direction. On the other hand, the gel-spun scaffolds have been implanted in mouse to examine the degradation rate in vivo and tissue in-growth aspects, compared to extruded scaffolds. Both shows very similar degradation rates, but the aspect in tissue in-growth was different. In conclusion, gel-spun PLCL scaffolds have good characteristics as a plausible scaffold for cardiovascular tissue engineering.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/107514
- DOI
- 10.4028/www.scientific.net/kem.342-343.321
- ISSN
- 1662-9795
- Article Type
- Article
- Citation
- Key Engineering Materials, vol. 342-343, page. 321 - 324, 2007-07
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- There are no files associated with this item.
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