Optimization of Scaffold for a Successful Hydrogel-Seeding Method for Vascular Tissue Engineering
SCIE
- Title
- Optimization of Scaffold for a Successful Hydrogel-Seeding Method for Vascular Tissue Engineering
- Authors
- Park, In Su; Kim, Sang Heon; HAN, JEONG WOO; Ko, Young Gun; Chung, Eun Na; Kim, Soo Hyun
- Date Issued
- 2007-07
- Publisher
- Trans Tech Publications, Ltd.
- Abstract
- Porosity and pore size are needed for successful cell seeding and proliferation into porous scaffolds. This study was focused on a hydrogel-seeding method to improve cell adhesion and proliferation in tubular porous scaffolds for vascular grafts application. Tubular scaffolds were fabricated from a biodegradable elastic polymer, poly(L-lactide-co-ε-caprolactone) (PLCL) (50:50, Mn 1.58×105), by an extrusion-particulate leaching method. Vascular smooth muscle cells (VSMCs) were dispersed in collagen hydrogel and then seeded into the tubular PLCL scaffolds having various pore sizes, 50-100 μm, 100-200 μm, and 300-500 μm, respectively. As a result, the efficiency of cell adhesion and proliferation was dependent on the pore size of the scaffolds. Especially, the cell proliferation efficiency was improved by using the hydrogel-seeding method as compared with by using a previously established method. In summary, this study demonstrates that the efficiency of cell adhesion and proliferation was dependent on the pore size of the scaffolds in the hydrogel-seeding method.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/107515
- DOI
- 10.4028/www.scientific.net/kem.342-343.333
- ISSN
- 1662-9795
- Article Type
- Article
- Citation
- Key Engineering Materials, vol. 342-343, page. 333 - 336, 2007-07
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- There are no files associated with this item.
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