hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in Response to Transient Oxygen–Glucose Deprivation in Hippocampal Neurons
SCIE
SCOPUS
- Title
- hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in Response to Transient Oxygen–Glucose Deprivation in Hippocampal Neurons
- Authors
- Kim, Sung Wook; Hong, In Kyung; Kim, Mingee; Song, Yun Seon; Kim, Kyong-Tai
- Date Issued
- 2021-12
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Abstract
- Protein aggregates of cofilin and actin have been found in neurons under oxygen-glucose deprivation. However, the regulatory mechanism behind the expression of Cfl1 during oxygen-glucose deprivation remains unclear. Here, we found that heterogeneous nuclear ribonucleoproteins (hnRNP) Q and hnRNP A1 regulate the translation of Cfl1 mRNA, and formation of cofilin-actin aggregates. The interaction between hnRNP A1 and Cfl1 mRNA was interrupted by hnRNP Q under normal conditions, while the changes in the expression and localization of hnRNP Q and hnRNP A1 increased such interaction, as did the translation of Cfl1 mRNA under oxygen-glucose deprived conditions. These findings reveal a new translational regulatory mechanism of Cfl1 mRNA in hippocampal neurons under oxygen-glucose deprivation.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/109172
- DOI
- 10.3390/cells10123567
- ISSN
- 2073-4409
- Article Type
- Article
- Citation
- Cells, vol. 10, no. 12, 2021-12
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- There are no files associated with this item.
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