Stereoselective Access to Tetra‐ and Tri‐Substituted Fluoro‐ and Chloro‐borylalkenes via Boron‐Wittig Reaction
SCIE
SCOPUS
- Title
- Stereoselective Access to Tetra‐ and Tri‐Substituted Fluoro‐ and Chloro‐borylalkenes via Boron‐Wittig Reaction
- Authors
- HAN, SEUNGCHEOL; LEE, YEOSAN; YUJIN, JUNGYUJIN; CHO, SEUNG HWAN
- Date Issued
- 2022-08
- Publisher
- John Wiley & Sons Ltd.
- Abstract
- Reported herein is the efficient synthesis of tetra- and tri-substituted ( Z )-fluoro- and ( Z )-chloro-borylalkenes by the Boron–Wittig reaction of ketones and aldehydes with bench-top stable halo-diborylmethanes. The substrate scope is broad and the Boron–Wittig reaction proceeds from a diverse range of ketones and aldehydes including biologically relevant molecules with fluoro- or chloro-diborylmethanes, providing tetra- and tri-substituted ( Z )-fluoro- and ( Z )-chloro-borylalkenes in good yields with high stereoselectivity. The utilities of the obtained ( Z )-fluoro- and ( Z )-chloro-borylalkenes are highlighted by further modifications to afford fluoroalkene derivatives or all-carbon substituted alkene.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/113655
- DOI
- 10.1002/anie.202210532
- ISSN
- 1433-7851
- Article Type
- Article
- Citation
- Angewandte Chemie - International Edition, vol. 61, no. 41, 2022-08
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- There are no files associated with this item.
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