DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jinhee Yoo | - |
dc.contributor.author | Donghyeon Oh | - |
dc.contributor.author | Chulhong Kim | - |
dc.contributor.author | KIM, HYUNG HAM | - |
dc.contributor.author | Ji-Yong Um | - |
dc.date.accessioned | 2023-03-15T00:50:21Z | - |
dc.date.available | 2023-03-15T00:50:21Z | - |
dc.date.created | 2023-03-14 | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 2156-7085 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/116992 | - |
dc.description.abstract | Photoacoustic (PA) imaging is a high-fidelity biomedical imaging technique based on the principle of molecular-specific optical absorption of biological tissue constitute. Because PA imaging shares the same basic principle as that of ultrasound (US) imaging, the use of PA/US dual-modal imaging can be achieved using a single system. However, because PA imaging is limited to a shallower depth than US imaging due to the optical extinction in biological tissue, the PA signal yields a lower signal-to-noise ratio (SNR) than US images. To selectively amplify the PA signal, we propose a switchable preamplifier for acoustic-resolution PA microscopy implemented on an application-specific integrated circuit. Using the preamplifier, we measured the increments in the SNR with both carbon lead and wire phantoms. Furthermore, in vivo whole-body PA/US imaging of a mouse with a preamplifier showed enhancement of SNR in deep tissues, unveiling deeply located organs and vascular networks. By selectively amplifying the PA signal range to a level similar to that of the US signal without contrast agent administration, our switchable amplifier strengthens the mutual complement between PA/US imaging. PA/US imaging is impending toward clinical translation, and we anticipate that this study will help mitigate the imbalance of image depth between the two imaging modalities. © 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement. | - |
dc.language | English | - |
dc.publisher | The Optical Society | - |
dc.relation.isPartOf | Biomedical Optics Express | - |
dc.title | Switchable preamplifier for dual modal photoacoustic and ultrasound imaging | - |
dc.type | Article | - |
dc.identifier.doi | 10.1364/BOE.476453 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Biomedical Optics Express, v.14, no.1 | - |
dc.identifier.wosid | 001032012100007 | - |
dc.citation.number | 1 | - |
dc.citation.title | Biomedical Optics Express | - |
dc.citation.volume | 14 | - |
dc.contributor.affiliatedAuthor | Chulhong Kim | - |
dc.contributor.affiliatedAuthor | KIM, HYUNG HAM | - |
dc.identifier.scopusid | 2-s2.0-85144603677 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Optics | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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