Switchable preamplifier for dual modal photoacoustic and ultrasound imaging
SCIE
SCOPUS
- Title
- Switchable preamplifier for dual modal photoacoustic and ultrasound imaging
- Authors
- Jinhee Yoo; Donghyeon Oh; Chulhong Kim; KIM, HYUNG HAM; Ji-Yong Um
- Date Issued
- 2023-01
- Publisher
- The Optical Society
- Abstract
- Photoacoustic (PA) imaging is a high-fidelity biomedical imaging technique based on the principle of molecular-specific optical absorption of biological tissue constitute. Because PA imaging shares the same basic principle as that of ultrasound (US) imaging, the use of PA/US dual-modal imaging can be achieved using a single system. However, because PA imaging is limited to a shallower depth than US imaging due to the optical extinction in biological tissue, the PA signal yields a lower signal-to-noise ratio (SNR) than US images. To selectively amplify the PA signal, we propose a switchable preamplifier for acoustic-resolution PA microscopy implemented on an application-specific integrated circuit. Using the preamplifier, we measured the increments in the SNR with both carbon lead and wire phantoms. Furthermore, in vivo whole-body PA/US imaging of a mouse with a preamplifier showed enhancement of SNR in deep tissues, unveiling deeply located organs and vascular networks. By selectively amplifying the PA signal range to a level similar to that of the US signal without contrast agent administration, our switchable amplifier strengthens the mutual complement between PA/US imaging. PA/US imaging is impending toward clinical translation, and we anticipate that this study will help mitigate the imbalance of image depth between the two imaging modalities. © 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/116992
- DOI
- 10.1364/BOE.476453
- ISSN
- 2156-7085
- Article Type
- Article
- Citation
- Biomedical Optics Express, vol. 14, no. 1, 2023-01
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