DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mun, Seul -Ki | - |
dc.contributor.author | Sim, Hyun Bo | - |
dc.contributor.author | Lee, Jae-Hyuk | - |
dc.contributor.author | Kim, Hyeongyeong | - |
dc.contributor.author | Park, Dae-Han | - |
dc.contributor.author | Lee, Yong-An | - |
dc.contributor.author | Han, Ji Yeon | - |
dc.contributor.author | Choi, Yu-Jeong | - |
dc.contributor.author | Son, Jun Sang | - |
dc.contributor.author | Park, Jeongwon | - |
dc.contributor.author | Lim, Tae-Hwan | - |
dc.contributor.author | Yee, Sung-Tae | - |
dc.contributor.author | Chang, Young-Tae | - |
dc.contributor.author | Lee, Seongsoo | - |
dc.contributor.author | Chang, Dong-Jo | - |
dc.contributor.author | Kim, Jong-Jin | - |
dc.date.accessioned | 2024-07-25T09:40:29Z | - |
dc.date.available | 2024-07-25T09:40:29Z | - |
dc.date.created | 2024-06-25 | - |
dc.date.issued | 2024-04 | - |
dc.identifier.issn | 1226-4601 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/123763 | - |
dc.description.abstract | Despite notable advancements in cancer therapeutics, metastasis remains a primary obstacle impeding a successful prognosis. Our prior study has identified heme oxygenase 2 (HO2) as a promising therapeutic biomarker for the aggressive subsets within tumor. This study aims to systematically evaluate HO2 as a therapeutic target of cancer, with a specific emphasis on its efficacy in addressing cancer metastasis. Through targeted inhibition of HO2 by TiNIR (tumor-initiating cell probe with near infrared), we observed a marked increase in reactive oxygen species. This, in turn, orchestrated the modulation of AKT and cJUN activation, culminating in a substantial attenuation of both proliferation and migration within a metastatic cancer cell model. Furthermore, in a mouse model, clear inhibition of cancer metastasis was unequivocally demonstrated with an HO2 inhibitor administration. These findings underscore the therapeutic promise of targeting HO2 as a strategic intervention to impede cancer metastasis, enhancing the effectiveness of cancer treatments. | - |
dc.language | English | - |
dc.publisher | The Korean Society for Biomaterials | BioMed Central | - |
dc.relation.isPartOf | Biomaterials Research | - |
dc.title | Targeting Heme Oxygenase 2 (HO2) with TiNIR, a Theragnostic Approach for Managing Metastatic Non-Small Cell Lung Cancer | - |
dc.type | Article | - |
dc.identifier.doi | 10.34133/bmr.0026 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Biomaterials Research, v.28 | - |
dc.identifier.wosid | 001220860600001 | - |
dc.citation.title | Biomaterials Research | - |
dc.citation.volume | 28 | - |
dc.contributor.affiliatedAuthor | Chang, Young-Tae | - |
dc.identifier.scopusid | 2-s2.0-85194504450 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | BIOMARKER | - |
dc.subject.keywordPlus | AXIS | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | kci | - |
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