Targeting Heme Oxygenase 2 (HO2) with TiNIR, a Theragnostic Approach for Managing Metastatic Non-Small Cell Lung Cancer
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KCI
- Title
- Targeting Heme Oxygenase 2 (HO2) with TiNIR, a Theragnostic Approach for Managing Metastatic Non-Small Cell Lung Cancer
- Authors
- Mun, Seul -Ki; Sim, Hyun Bo; Lee, Jae-Hyuk; Kim, Hyeongyeong; Park, Dae-Han; Lee, Yong-An; Han, Ji Yeon; Choi, Yu-Jeong; Son, Jun Sang; Park, Jeongwon; Lim, Tae-Hwan; Yee, Sung-Tae; Chang, Young-Tae; Lee, Seongsoo; Chang, Dong-Jo; Kim, Jong-Jin
- Date Issued
- 2024-04
- Publisher
- The Korean Society for Biomaterials | BioMed Central
- Abstract
- Despite notable advancements in cancer therapeutics, metastasis remains a primary obstacle impeding a successful prognosis. Our prior study has identified heme oxygenase 2 (HO2) as a promising therapeutic biomarker for the aggressive subsets within tumor. This study aims to systematically evaluate HO2 as a therapeutic target of cancer, with a specific emphasis on its efficacy in addressing cancer metastasis. Through targeted inhibition of HO2 by TiNIR (tumor-initiating cell probe with near infrared), we observed a marked increase in reactive oxygen species. This, in turn, orchestrated the modulation of AKT and cJUN activation, culminating in a substantial attenuation of both proliferation and migration within a metastatic cancer cell model. Furthermore, in a mouse model, clear inhibition of cancer metastasis was unequivocally demonstrated with an HO2 inhibitor administration. These findings underscore the therapeutic promise of targeting HO2 as a strategic intervention to impede cancer metastasis, enhancing the effectiveness of cancer treatments.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/123763
- DOI
- 10.34133/bmr.0026
- ISSN
- 1226-4601
- Article Type
- Article
- Citation
- Biomaterials Research, vol. 28, 2024-04
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- There are no files associated with this item.
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