Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box
SCIE
SCOPUS
- Title
- Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box
- Authors
- Kim, HY; Cho, Y
- Date Issued
- 1997-05
- Publisher
- Nature Publishing Group
- Abstract
- The pocket region of retinoblastoma tumour suppressor (Rb) is essential for tumour suppressing activity. The Rb pocket is primarily composed of two domains, A and B. We have determined the X-ray crystal structure of domain A (residues 378-562) at 2.3 Angstrom resolution. Domain A consists of nine alpha-helices. The overall arrangement of helices in domain A is remarkably similar to the cyclin-box folds found in the crystal structures of cyclin A and TFIIB. This structure, along with domain B which is predicted to be homologous to the cyclin-box, suggests that the Rb pocket is composed of two cyclin-box fold domains. We present the structural/functional features of the Rb pocket, and the potential binding region for cellular or viral proteins within domain A.
- Keywords
- GENE-PRODUCT; RB GENE; CRYSTAL-STRUCTURE; PROTEIN; PROGRAM; DOMAIN; TFIIB; COMPLEX; BINDING; RECOGNITION
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/16307
- DOI
- 10.1038/nsb0597-390
- ISSN
- 1072-8368
- Article Type
- Article
- Citation
- NATURE STRUCTURAL BIOLOGY, vol. 4, no. 5, page. 390 - 395, 1997-05
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