Hepatitis C virus core protein promotes cell proliferation through the upregulation of cyclin E expression levels
SCIE
SCOPUS
- Title
- Hepatitis C virus core protein promotes cell proliferation through the upregulation of cyclin E expression levels
- Authors
- Cho, JW; Baek, WK; Suh, SI; Yang, SH; Chang, J; Sung, YC; Suh, MH
- Date Issued
- 2001-04
- Publisher
- MUNKSGAARD INT PUBL LTD
- Abstract
- Aims/Background: The hepatitis C virus (HCV) core protein is known to Flay an important role in hepatocarcinogenesis. Recent studies have suggested that the increased proliferation rate of hepatocytes is a major risk factor for the development of hepatocellular carcinoma. In this study, we investigated whether the HCV core protein promotes the cell growth rate through the modulation of cyclin E expression levels. Methods/Results: HCV core stable transfectant Rat-1 cell lines showed a markedly increased proliferation rate compared to mock cells. Cyclin E expression and its associated kinase activities were remarkably increased in HCV core stable transfect;mts, Cyclin E mRNA levels were also upregulated in these eel lines. Conclusions: Our data suggest that the HCV core protein promotes cell proliferation through upregulation of the cyclin E expression levels, implying this property of HCV core protein plays an important role in hepatocarcinogenesis.
- Keywords
- hepatitis C virus; core protein; cyclin E; hepatocarcinogenesis; RAT EMBRYO FIBROBLASTS; BREAST-CANCER; G(1); G(1)-CYCLINS; ACCELERATION
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/19560
- DOI
- 10.1034/j.1600-0676.2001.021002137.x
- ISSN
- 0106-9543
- Article Type
- Article
- Citation
- LIVER, vol. 21, no. 2, page. 137 - 142, 2001-04
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- There are no files associated with this item.
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