DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, HY | - |
dc.contributor.author | Ahn, BY | - |
dc.contributor.author | Cho, Y | - |
dc.date.accessioned | 2016-03-31T14:01:09Z | - |
dc.date.available | 2016-03-31T14:01:09Z | - |
dc.date.created | 2009-03-05 | - |
dc.date.issued | 2001-01-15 | - |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.other | 2001-OAK-0000010271 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/20998 | - |
dc.description.abstract | Inactivation of the retinoblastoma (Rb) tumor suppressor by Simian virus 40 (SV40) large T antigen is one of the central features of tumorigenesis induced by SV40. Both the N-terminal J domain and the LxCxE motif of large T antigen are required for inactivation of Rb, The crystal structure of the N-terminal region (residues 7-117) of SV40 large T antigen bound to the pocket domain of Rb reveals that large T antigen contains a four-helix bundle, and residues from helices alpha2 and alpha4 and from a loop containing the LxCxE motif participate in the interactions with Rb. The two central helices and a connecting loop in large T antigen have structural similarities with the J domains of the molecular chaperones DnaJ and HDJ-1, suggesting that large T antigen may use a chaperone mechanism for its biological function. However, there are significant differences between large T antigen and the molecular chaperones in other regions and these differences are likely to provide the specificity needed for large T antigen to inactivate Rb. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.relation.isPartOf | EMBO JOURNAL | - |
dc.subject | chaperone mechanism | - |
dc.subject | Rb tumor suppressor | - |
dc.subject | SV40 large T antigen | - |
dc.subject | viral oncogene | - |
dc.subject | SIMIAN-VIRUS-40 LARGE-T | - |
dc.subject | ESCHERICHIA-COLI DNAJ | - |
dc.subject | CELL-CYCLE CONTROL | - |
dc.subject | J-DOMAIN | - |
dc.subject | GENE-PRODUCT | - |
dc.subject | TRANSCRIPTION FACTOR | - |
dc.subject | SUSCEPTIBILITY GENE | - |
dc.subject | MOLECULAR CHAPERONE | - |
dc.subject | CRYSTAL-STRUCTURE | - |
dc.subject | FAMILY PROTEINS | - |
dc.title | Structural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigen | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1093/emboj/20.1.295 | - |
dc.author.google | Kim, HY | - |
dc.author.google | Ahn, BY | - |
dc.author.google | Cho, Y | - |
dc.relation.volume | 20 | - |
dc.relation.issue | 1-2 | - |
dc.relation.startpage | 295 | - |
dc.relation.lastpage | 304 | - |
dc.contributor.id | 10082321 | - |
dc.relation.journal | EMBO JOURNAL | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | EMBO JOURNAL, v.20, no.1-2, pp.295 - 304 | - |
dc.identifier.wosid | 000166555700031 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 304 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 295 | - |
dc.citation.title | EMBO JOURNAL | - |
dc.citation.volume | 20 | - |
dc.contributor.affiliatedAuthor | Cho, Y | - |
dc.identifier.scopusid | 2-s2.0-0035863048 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 124 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SIMIAN-VIRUS-40 LARGE T | - |
dc.subject.keywordPlus | J-DOMAIN | - |
dc.subject.keywordPlus | CELL-CYCLE | - |
dc.subject.keywordPlus | SUSCEPTIBILITY GENE | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | BINDING PROTEIN | - |
dc.subject.keywordPlus | PRB-BINDING | - |
dc.subject.keywordPlus | DNAJ | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordAuthor | chaperone mechanism | - |
dc.subject.keywordAuthor | Rb tumor suppressor | - |
dc.subject.keywordAuthor | SV40 large T antigen | - |
dc.subject.keywordAuthor | viral oncogene | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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