Mel-18, a mammalian Polycomb gene, regulates angiogenic gene expression of endothelial cells
SCIE
SCOPUS
- Title
- Mel-18, a mammalian Polycomb gene, regulates angiogenic gene expression of endothelial cells
- Authors
- Jung, JH; Choi, HJ; Maeng, YS; Choi, JY; Kim, M; Kwon, JY; Park, YW; Kim, YM; Hwang, D; Kwon, YG
- Date Issued
- 2010-10-01
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Abstract
- Mel-18 is a mammalian homolog of Polycomb group (PcG) genes. Microarray analysis revealed that Mel-18 expression was induced during endothelial progenitor cell (EPC) differentiation and correlates with the expression of EC-specific protein markers. Overexpression of Mel-18 promoted EPC differentiation and angiogenic activity of ECs. Accordingly, silencing Mel-18 inhibited EC migration and tube formation in vitro. Gene expression profiling showed that Mel-18 regulates angiogenic genes including kinase insert domain receptor (KDR), claudin 5, and angiopoietin-like 2. Our findings demonstrate, for the first time, that Mel-18 plays a significant role in the angiogenic function of ECs by regulating endothelial gene expression. (C) 2010 Elsevier Inc. All rights reserved.
- Keywords
- Mel-18; Polycomb group gene; Endothelial cells; Differentiation; Angiogenesis; PROGENITOR CELLS; MICE
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/25322
- DOI
- 10.1016/J.BBRC.2010.08.086
- ISSN
- 0006-291X
- Article Type
- Article
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 400, no. 4, page. 523 - 530, 2010-10-01
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