Stimulation of tumor growth by human soluble intercellular adhesion molecule-1.
SCIE
SCOPUS
- Title
- Stimulation of tumor growth by human soluble intercellular adhesion molecule-1.
- Authors
- Gho, YS; Phillia N. Kim; Hao-Chuan Li; Michael Elkin; Hynda K Kleinman
- Date Issued
- 2001-05-15
- Publisher
- AMER ASSOC CANCER RESEARCH
- Abstract
- Because serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) are elevated in cancer and sICAM-1 is angiogenic, we tested the ability of sICAM-1 to promote tumor growth. Our preliminary experiments showed that exogenous sICAM-1 significantly stimulated the growth of human tumors in vivo. Human fibrosarcoma transfectants, which express ICAM-1, produce ICAM-1 on the cell surface and release sICAM-1 into the medium without any apparent effect on cell growth in vitro. We found that conditioned medium from sense ICAM-1 transfectants compared with mock or antisense ICAM-1 transfectants stimulates endothelial cell migration in vitro and neovascularization in the chick chorioallantoic membrane assay. Tumor cells transfected with sense constructs form faster growing tumors than mock- and antisense-transfected cells in both chick embryos and nude mice models. Serum levels of human sICAM-1 from nude mice bearing sense ICAM-1 transfectants correlate positively with tumor weight. Sense ICAM-1 transfectants are more proliferative and induce more blood vessel formation than mock and anti-sense transfectants in nude mice. Because expression of ICAM-1 does not affect tumor cell growth in vitro, the angiogenic activity of sICAM-1 produced by sense ICAM-1 transfectants may be involved in the stimulation of tumor growth. Therefore, sICAM-1 may perform dual functions that are essential for tumor growth: angiogenesis and escape from immune surveillance.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/28394
- ISSN
- 0008-5472
- Article Type
- Article
- Citation
- CANCER RESEARCH, vol. 61, no. 10, page. 4253 - 4257, 2001-05-15
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