DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nurieva, RI | - |
dc.contributor.author | Chung, Y | - |
dc.contributor.author | Hwang, D | - |
dc.contributor.author | Yang, XO | - |
dc.contributor.author | Kang, HS | - |
dc.contributor.author | Ma, L | - |
dc.contributor.author | Wang, YH | - |
dc.contributor.author | Watowich, SS | - |
dc.contributor.author | Jetten, AM | - |
dc.contributor.author | Tian, Q | - |
dc.contributor.author | Dong, C | - |
dc.date.accessioned | 2016-04-01T09:03:00Z | - |
dc.date.available | 2016-04-01T09:03:00Z | - |
dc.date.created | 2011-04-04 | - |
dc.date.issued | 2008-07-18 | - |
dc.identifier.issn | 1074-7613 | - |
dc.identifier.other | 2008-OAK-0000011003 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/29342 | - |
dc.description.abstract | After activation, CD4(+) helper T (Th) cells differentiate into distinct effector subsets. Although chemokine (C-X-C motif]I receptor 5-expressing T follicular helper (Tfh) cells are important in humoral immunity, their developmental regulation is unclear. Here we show that Tfh cells had a distinct gene expression profile and developed in vivo independently of the Th1 or Th2 cell lineages. Tfh cell generation was regulated by ICOS ligand (ICOSL) expressed on B cells and was dependent on interleukin-21 (IL-21), IL-6, and signal transducer and activator of transcription 3 (STAT3). However, unlike Th17 cells, differentiation of Tfh cells did not require transforming growth factor 0 (TGF-beta) or Th17-specific orphan nuclear receptors ROR alpha and ROR gamma in vivo. Finally, naive T cells activated in vitro in the presence of IL-21 but not TGF-beta signaling preferentially acquired Tfh gene expression and promoted germinal-center reactions in vivo. This study thus demonstrates that Tfh is a distinct Th cell lineage. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.relation.isPartOf | IMMUNITY | - |
dc.subject | CXC CHEMOKINE RECEPTOR-5 | - |
dc.subject | B-CELLS | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | ROR-GAMMA | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | RESPONSES | - |
dc.subject | AUTOIMMUNITY | - |
dc.subject | IL-21 | - |
dc.subject | BETA | - |
dc.subject | T(H)17 | - |
dc.title | Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1016/J.IMMUNI.2008.05.009 | - |
dc.author.google | Nurieva, RI | - |
dc.author.google | Chung, Y | - |
dc.author.google | Hwang, D | - |
dc.author.google | Yang, XO | - |
dc.author.google | Kang, HS | - |
dc.author.google | Ma, L | - |
dc.author.google | Wang, YH | - |
dc.author.google | Watowich, SS | - |
dc.author.google | Jetten, AM | - |
dc.author.google | Tian, Q | - |
dc.author.google | Dong, C | - |
dc.relation.volume | 29 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 138 | - |
dc.relation.lastpage | 149 | - |
dc.contributor.id | 10180943 | - |
dc.relation.journal | IMMUNITY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | IMMUNITY, v.29, no.1, pp.138 - 149 | - |
dc.identifier.wosid | 000257905400017 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 149 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 138 | - |
dc.citation.title | IMMUNITY | - |
dc.citation.volume | 29 | - |
dc.contributor.affiliatedAuthor | Hwang, D | - |
dc.identifier.scopusid | 2-s2.0-46749151286 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 699 | - |
dc.description.scptc | 659 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CXC CHEMOKINE RECEPTOR-5 | - |
dc.subject.keywordPlus | B-CELLS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | ROR-GAMMA | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | AUTOIMMUNITY | - |
dc.subject.keywordPlus | IL-21 | - |
dc.subject.keywordPlus | BETA | - |
dc.subject.keywordPlus | T(H)17 | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
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