Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
SCIE
SCOPUS
- Title
- Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
- Authors
- Nurieva, RI; Chung, Y; Hwang, D; Yang, XO; Kang, HS; Ma, L; Wang, YH; Watowich, SS; Jetten, AM; Tian, Q; Dong, C
- Date Issued
- 2008-07-18
- Publisher
- CELL PRESS
- Abstract
- After activation, CD4(+) helper T (Th) cells differentiate into distinct effector subsets. Although chemokine (C-X-C motif]I receptor 5-expressing T follicular helper (Tfh) cells are important in humoral immunity, their developmental regulation is unclear. Here we show that Tfh cells had a distinct gene expression profile and developed in vivo independently of the Th1 or Th2 cell lineages. Tfh cell generation was regulated by ICOS ligand (ICOSL) expressed on B cells and was dependent on interleukin-21 (IL-21), IL-6, and signal transducer and activator of transcription 3 (STAT3). However, unlike Th17 cells, differentiation of Tfh cells did not require transforming growth factor 0 (TGF-beta) or Th17-specific orphan nuclear receptors ROR alpha and ROR gamma in vivo. Finally, naive T cells activated in vitro in the presence of IL-21 but not TGF-beta signaling preferentially acquired Tfh gene expression and promoted germinal-center reactions in vivo. This study thus demonstrates that Tfh is a distinct Th cell lineage.
- Keywords
- CXC CHEMOKINE RECEPTOR-5; B-CELLS; GENE-EXPRESSION; ROR-GAMMA; DIFFERENTIATION; RESPONSES; AUTOIMMUNITY; IL-21; BETA; T(H)17
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/29342
- DOI
- 10.1016/J.IMMUNI.2008.05.009
- ISSN
- 1074-7613
- Article Type
- Article
- Citation
- IMMUNITY, vol. 29, no. 1, page. 138 - 149, 2008-07-18
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