DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, MJ | - |
dc.contributor.author | Yoo, JY | - |
dc.date.accessioned | 2016-04-01T09:03:26Z | - |
dc.date.available | 2016-04-01T09:03:26Z | - |
dc.date.created | 2009-08-11 | - |
dc.date.issued | 2008-11-15 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.other | 2008-OAK-0000010978 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/29359 | - |
dc.description.abstract | Caspase-1 is an inflammatory caspase that controls the activation and secretion of the inflammatory cytokines, IL-1 beta and IL-18. We observed that cellular levels of retinoic acid-inducible gene-I (RIG-I) were enhanced when the pan-caspase inhibitor Z-VAD-fmk or caspase-1-specific inhibitor Z-WEHD-fmk blocked caspase activity. Overexpression of caspase-1 reduced cellular levels of RIG-I and inhibited RIG-I-mediated signaling activity. Enzymatic activity of caspase-1 was necessary to control RIG-I, although it was not a substrate of proteolytic cleavage by caspase-1. Caspase-1 physically interacted with full length RIG-I, but not with mutant forms lacking either the amino- or carboxyl-terminal domains. RIG-I was present in the supernatant of cells transfected with active caspase-1 but not with caspase-4. Stimulating cells with LPS and ATP also induced secretion of endogenous RIG-I in macrophages. Our data suggest a novel mechanism that negatively regulates RIG-I-mediated signaling activity via caspase-1-dependent secretion of RIG-I protein. The Journal of Immunology, 2008, 181: 7324-7331. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.title | Active Caspase-1-Mediated Secretion of Retinoic Acid Inducible Gene-I | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.4049/jimmunol.181.10.7324 | - |
dc.author.google | Kim, MJ | - |
dc.author.google | Yoo, JY | - |
dc.relation.volume | 181 | - |
dc.relation.issue | 10 | - |
dc.relation.startpage | 7324 | - |
dc.relation.lastpage | 7331 | - |
dc.contributor.id | 10114821 | - |
dc.relation.journal | JOURNAL OF IMMUNOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCOPUS | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.181, no.10, pp.7324 - 7331 | - |
dc.identifier.wosid | 000260913900074 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 7331 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 7324 | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 181 | - |
dc.contributor.affiliatedAuthor | Yoo, JY | - |
dc.identifier.scopusid | 2-s2.0-58149185720 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 12 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | RIG-I | - |
dc.subject.keywordPlus | NEGATIVE REGULATION | - |
dc.subject.keywordPlus | UBIQUITIN LIGASE | - |
dc.subject.keywordPlus | RNA | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | INFLAMMASOME | - |
dc.subject.keywordPlus | INTERLEUKIN-1-BETA | - |
dc.subject.keywordPlus | IL-1-BETA | - |
dc.subject.keywordPlus | DNA | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
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