Loss of phospholipase D2 impairs VEGF-induced angiogenesis
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- Title
- Loss of phospholipase D2 impairs VEGF-induced angiogenesis
- Authors
- 이창섭; 김재왕; 송박용; 서판길; 류성호
- Date Issued
- 2016-03
- Publisher
- 생화학분자생물학회
- Abstract
- Vascular endothelial growth factor (VEGF) is a key mediator of angiogenesis and critical for normal embryonic development and repair of pathophysiological conditions in adults. Although phospholipase D (PLD) activity has been implicated in angiogenic processes, its role in VEGF signaling during angiogenesis in mammals is unclear. Here, we found that silencing of PLD2 by siRNA blocked VEGF-mediated signaling in immortalized human umbilical vein endothelial cells (iHUVECs).
Also, VEGF-induced endothelial cell survival, proliferation, migration, and tube formation were inhibited by PLD2 silencing.
Furthermore, while Pld2-knockout mice exhibited normal development, loss of PLD2 inhibited VEGF-mediated ex vivo angiogenesis. These findings suggest that PLD2 functions as a key mediator in the VEGF-mediated angiogenic functions of endothelial cells.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/37655
- DOI
- 10.5483/BMBREP.2016.49.3.219
- ISSN
- 1976-6696
- Article Type
- Article
- Citation
- BMB Reports, vol. 49, no. 3, page. 191 - 196, 2016-03
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