Doxorubicin/Ce6-Loaded Nanoparticle Coated with Polymer via Singlet Oxygen-Sensitive Linker for Photodynamically Assisted Chemotherapy
SCOPUS
- Title
- Doxorubicin/Ce6-Loaded Nanoparticle Coated with Polymer via Singlet Oxygen-Sensitive Linker for Photodynamically Assisted Chemotherapy
- Authors
- Junseok Lee,; Yeong Mi Lee; Jinhwan Kim; KIM, WON JONG
- Date Issued
- 2017-05
- Publisher
- Ivyspring International Publisher
- Abstract
- It is widely known that the therapeutic effect of nanoparticle-based chemotherapeutics could be greatly enhanced by the introduction of the photodynamic effect. Herein we report a chlorin e6-incorporated mesoporous silica nanoparticles (MSNs) covered with a polyethylene glycol shell conjugated via a singlet oxygen-sensitive labile bis(alkylthio)alkene linker (CeAP-L-PEG). In this study, single irradiation with biocompatible red light induced both intracellular doxorubicin release and photochemical internalization, and consequently enhanced anti-cancer effect was observed in vitro and in vivo. This study suggests the potential of our precisely designed nanoparticle system for photodynamically assisted chemotherapy.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/41239
- DOI
- 10.7150/ntno.18576
- ISSN
- 2206-7418
- Article Type
- Article
- Citation
- NanoTheranostics, vol. 1, no. 2, page. 196 - 207, 2017-05
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- There are no files associated with this item.
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