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Autism-Like Behavior Caused by Deletion of Vaccinia-related Kinase 3 is Improved by TrkBStimulation
- Title
- Autism-Like Behavior Caused by Deletion of Vaccinia-related Kinase 3 is Improved by TrkBStimulation
- Authors
- 류혜국; MYUNG, SU KANG; CHOI TEAYONG; 이도현; 이승현; 최세영; KIM, KYONG TAI
- Date Issued
- 2017-08-30
- Publisher
- KSBNS
- Abstract
- Vaccinia-relatedkinases(VRKs)aremultifacetedserine/threoninekinasesthatplayessentialrolesinvariousaspectsofcellsignaling,cellcycleprogression,apoptosis,andneuronaldevelopmentanddifferentiation.However,theneuronalfunctionofVRK3isstillunknowninspiteofitsetiologicalpotentialinhumanautismspectrumdisorder(ASD).Here,wereportthatVRK3-deficientmiceexhibitedtypicalsymptomsofautism-likebehaviorincludinghyperactivity,stereotypedbehaviors,reducedsocialinteraction,andimpairedcontextdependentspatialmemory.SignificantdecreaseindendriticspinenumberandarborizationwereidentifiedinthehippocampusCA1ofVRK3-deficientmice.ThesemicealsoexhibitedareducedrectificationofAMPAreceptor-mediatedcurrentandchangesinexpressionofsynapticandsignalingproteinsincludingTrkB,ArcandCaMKIIα.Notably,TrkBstimulationwith7,8-dihydroxyflavone(7,8-DHF)reversedthealteredsynapticstructureandfunction,andsuccessfullyrestoredautism-likebehaviorinVRK3-deficientmice.TheseresultsrevealthatVRK3playsacriticalroleinneurodevelopmentaldisordersandsuggestapotentialtherapeuticstrategyforASD.
- Article Type
- Conference
- Citation
- The 20th Annual Meeting of the Korean Society Brain and Neural Science Co-organized by the Korean Society for Neurodegenerative Disease, 2017-08-30
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Related Researcher
- 김경태KIM, KYONG TAI
- Dept of Life Sciences