Inhibitory activity of a ceramide library on interleukin-4 production from activated T cells
SCIE
SCOPUS
- Title
- Inhibitory activity of a ceramide library on interleukin-4 production from activated T cells
- Authors
- Park, J; Li, Q; Chang, Young-Tae; Kim, TS
- Date Issued
- 2005-04
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Abstract
- Allergic diseases are hypersensitivity disorders associated with the production of specific immunoglobulin E (IgE) to environmental allergens. Interleukin (IL)-4, produced primarily by CD4(+) T cells, is an important stimulus for the switch of the antibody isotype to IgE in both mice and humans. In this study we investigated the inhibitory activity of IL-4 production in activated T cells by screening ceramide derivatives prepared by solid phase combinatorial chemistry. Many ceramide derivatives significantly inhibited IL-4 production in T cells. In particular, ceramide derivatives with a lauroyl group showed strong inhibitory activities on IL-4 production in both phorbol 12-myristate 13-acetate (PMA)-activated EL4 T cells and antigen-primed cells, suggesting that they can be used as compounds for the development of anti-allergic agents. (c) 2005 Elsevier Ltd. All rights reserved.
- Keywords
- TRANSCRIPTION FACTOR GATA-3; HUMAN IL-4 PROMOTER; IMMUNE-RESPONSE; DOWN-REGULATION; NUCLEAR FACTOR; HL-60 CELLS; TH2 CELLS; B-CELLS; NF-ATC; EXPRESSION
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50157
- DOI
- 10.1016/j.bmc.2005.01.027
- ISSN
- 0968-0896
- Article Type
- Article
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY, vol. 13, no. 7, page. 2589 - 2595, 2005-04
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