DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li, Qian | - |
dc.contributor.author | Min, Jaeki | - |
dc.contributor.author | Ahn, Young-Hoon | - |
dc.contributor.author | Namm, Joshua | - |
dc.contributor.author | Kim, Eun Min | - |
dc.contributor.author | Lui, Rowena | - |
dc.contributor.author | Kim, Hye Yun | - |
dc.contributor.author | Ji, Yong | - |
dc.contributor.author | Wu, Hueizhi | - |
dc.contributor.author | Wisniewski, Thomas | - |
dc.contributor.author | Chang, Young-Tae | - |
dc.date.accessioned | 2018-06-15T05:14:38Z | - |
dc.date.available | 2018-06-15T05:14:38Z | - |
dc.date.created | 2017-09-08 | - |
dc.date.issued | 2007-09 | - |
dc.identifier.issn | 1439-4227 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/50253 | - |
dc.description.abstract | A group of styryl-based neutral compounds has been synthesized in this study for potential use as in vivo imaging agents for beta-amyloid plaques. Of 56 candidates, 14 compounds were found to label beta-amyloid plaques well on Alzheimer's disease (AD) human brain sections in vitro. The binding affinity to beta-amyloid fibrils was then determined by measuring the change in fluorescence intensity. Interestingly, we found that a class of quinaldine-styryl scaffold compounds displays specific binding to beta-amyloid fibrils. A representative compound, STB-8, was used in ex vivo and in vivo imaging experiments on an AD transgenic mouse model and demonstrated excellent blood-brain barrier (BBB) permeability and specific staining of the AD beta-amyloid plaques. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.relation.isPartOf | CHEMBIOCHEM | - |
dc.subject | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | CONGO-RED | - |
dc.subject | BENZOFURAN DERIVATIVES | - |
dc.subject | PEPTIDE FIBRILS | - |
dc.subject | BINDING-SITES | - |
dc.subject | CHRYSAMINE-G | - |
dc.subject | BRAIN | - |
dc.subject | DEPOSITS | - |
dc.subject | PROBES | - |
dc.title | Styryl-based compounds as potential in vivo imaging agents for beta-amyloid plaques | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/cbic.200700154 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | CHEMBIOCHEM, v.8, no.14, pp.1679 - 1687 | - |
dc.identifier.wosid | 000249912100012 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 1687 | - |
dc.citation.number | 14 | - |
dc.citation.startPage | 1679 | - |
dc.citation.title | CHEMBIOCHEM | - |
dc.citation.volume | 8 | - |
dc.contributor.affiliatedAuthor | Chang, Young-Tae | - |
dc.identifier.scopusid | 2-s2.0-34948887647 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 50 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | CONGO-RED | - |
dc.subject.keywordPlus | BENZOFURAN DERIVATIVES | - |
dc.subject.keywordPlus | PEPTIDE FIBRILS | - |
dc.subject.keywordPlus | BINDING-SITES | - |
dc.subject.keywordPlus | CHRYSAMINE-G | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | DEPOSITS | - |
dc.subject.keywordPlus | PROBES | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
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